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UCHL1 inhibits BACE1. 9 / 9
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"In this study we demonstrated that Uch-L1 inhibition induces BACE1 up-regulation and increases neuronal and apoptotic cell death in control as well as in transgenic AD mouse model subjected to Bengal Rose, a light sensitive dye inducing that induces a cortical infarction through photo activation."
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"For example, the expression of circRNA ciRS-7, which originates from cerebellar degeneration-related protein 1 antisense transcript (CDR1AS), leads to the activation of Ubiquitin C-Terminal Hydrolase L1 (UCHL1), which then promotes APP and BACE1 degradation, consequently leading to impeded amyloid plaque growth [128]."
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"These results demonstrated that UCHL1 accelerates BACE1 degradation and affects APP processing and Abeta production."
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"23 The next cause of Aβ loss in fibrosis is the up‐regulation of ubiquitin carboxyl‐terminal hydrolase L1 (UCHL1, Figure 2F) which is known to decrease the BACE catalyzed cleavage of an APP fragment, C99, hereby reducing the Aβ levels in vitro as shown previously in HUCH cells."
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"Interestingly, the results indicated that the overexpression of UCHL1 decreased BACE1, and also alleviated the METH-induced up-regulation of BACE1 obviously ( Fig. 4 B, B1)."
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"In this study, we found that METH exposure led to the up-regulation of BACE1 by inhibiting UCHL1, which indicated that the UPS might be involved in the process.Moreover, autophagy may also play an imp[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Our data also suggest that ciRS-7 modulates APP and BACE1 levels in a nuclear factor-kappaB (NF-kappaB)-dependent manner : ciRS-7 expression inhibits translation of NF-kappaB and induces its cytoplasmic localization, thus derepressing expression of UCHL1, which promotes APP and BACE1 degradation."
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"In this study we demonstrated that the inhibition of Uch-L1 induces BACE1 up-regulation and increases neuronal cell death in control as well as in AD transgenic mouse models subjected to Bengal Rose, a light sensitive dye inducing a cortical infarction through photo activation."
29033830
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"Specifically, UCH-L1 appears to increase lysosomal degradation of BACE1, as inhibition of UCH-L1 caused a significant increase in BACE1 protein levels in several cell types, and loss of UCH-L1 gene function in gad mice significantly increased levels of endogenous BACE1, C99, and Abeta peptides [XREF_BIBR, XREF_BIBR]."
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