IndraLab

Statements

CYLD activates Cell Survival. 7 / 7
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"CYLD is among the most frequently mutated genes in multiple myeloma and likely contributes to the persistent NF-kappaB activation and enhanced cell survival in these tumors."
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"Downregulation of CYLD promoted cell survival and migratory activities through NF-kappaB activation, whereas CYLD overexpression inhibited those activities in MDA-MB-231 cells."
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"miR-19a is a member of the miR-17-92 cluster and has been shown to be overexpressed in T-cell acute lymphoblastic leukemia and multiple myeloma where it was revealed that miR-19a negatively regulates the expression of CYLD and SOCS-1 respectively to promote cell survival and pathogenesis [XREF_BIBR, XREF_BIBR]."
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"CYLD deficiency promotes cancer cell proliferation, cell survival and tumorigenesis."
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"We focused on investigation of the mechanism by which CYLD promotes cell survival in Mel-CV and ME1007 cells."
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"The decrease in cell viability caused by CYLD knockdown was due to induction of apoptosis, as it was associated with activation of the caspase cascade and was abolished by treatment with a general caspase inhibitor."
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"Strikingly, while CYLD silencing decreased cell viability as measured using CellTiter-Glo assays in Mel-CV and ME1007 cells, it resulted in a moderate yet statistically significant increase in cell viability in ME4405 cells and had no effect on the viability of Mel-FH cells (XREF_FIG)."
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