IndraLab
Statements
"In the p53-dependent pathway, p53 accumulates following E2F1 expression [29] through activation of the cyclin-dependent kinase inhibitor 2A (CDKN2A) transcript p14ARF, which in turn interacts with mouse double minutes (MDM2), thereby preventing MDM2 from targeting p53 for ubiquitination and subsequent degradation"
"Co-exposure to C75 and Taxol induced a remarkable nuclear accumulation of activated p38 mitogen-activated protein kinase (p38 MAPK), which was accompanied by a synergistic nuclear accumulation of the p53 tumor-suppressor protein that was phosphorylated at Ser46, a p38 MAPK-regulated pro-apoptotic modification of p53"