IndraLab

Statements

UCHL5 activates XRCC1. 5 / 5
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"Tumor-infiltrating B cells play a role in UCHL5-mediated promotion of RCC in late stage."
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"This suggests that UCHL5, like UCHL3, may also promote RCC by regulating immune cell infiltration and activity."
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"Therefore, we hypothesized that UCHL5 promotes RCC by inhibiting antigen process and presentation in RCC-infiltrating B cells."
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"The remodeling of the tumor microenvironment may be one of the factors contributing to the promotion of RCC by UCHL3 and UCHL5."
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"In contrast to BAP1, which inhibits RCC by upregulation of STING activity and activation of interferon, UCHL5 promotes RCC by regulating immune infiltration and antigen presentation of B cells, and its increased level in RCC blood samples suggest its potential as a prognostic marker."
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