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"In fact, it has been reported that COPS5 (also known as JAB1) was upregulated in HCC, and loss of COPS5 could inhibit the growth of HCC cells by restoring the expression of p57.33,34 Jun Yu etal found that UCHL1 was expressed in all normal tissues and immortalized normal epithelial cell lines but was low or silenced in 77% (10/13) of HCC cell lines."