IndraLab

Statements

Transferase methylates TP53 on lysine. 2 / 2
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"Methyl transferase enzymes (PRMT5—protein arginine methyltransferase 5, KMTs —lysine, K methyltransferases, SMYD2—SET And MYND domain containing 2, SET7/9, SET8—SET domain-containing proteins) can methylate several Lys and Arg residues of p53 during DNA damage response."
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"C-terminal lysine residues of p53 are methylated in vivo at K370, K372, K373, and K382 by histone lysine methyl transferases, Smyd2, SET9, G9a/Glp, and Set8, respectively. xref – xref While K372 methylation by SET9 in human cells enhanced p53 transcriptional activities, the role of p53 methylation in the mouse by Set7/9 was controversial. xref – xref However, it should be pointed out that the results from mouse embryonic fibroblasts in the mouse study might be inappropriate to apply to human epithelial cells."
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