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USP14 activates AKT. 2 / 2
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"As reported, USP14 was activated by AKT,32 so the non‐effect of mTOR activator on SPAG5 indicated that it was AKT, rather than mTOR that activated USP14 and led to upregulation of SPAG5 level in HG‐treated HPCs."
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"19 In addition, small USP14 inhibitors, such as WP1130, b‐AP15, AC17, and pyrithione, could dramatically suppressed cell proliferation and promoted apoptosis in various malignancies.9, 20, 21, 22, 23, 24 However, we did not observe any disturbed biological process, such as cell cycle progression, cell proliferation, and apoptosis, in USP14‐deficient GC cells, although silencing of USP14 dramatically inhibited Akt and ERK signaling pathways."
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