IndraLab

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PSMD14 increases the amount of SMAD3. 4 / 4
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"The three DUBs, POH1, YOD1, and USP37, markedly increased Smad3 protein levels in a dose-dependent manner ( Fig. 1 A)."
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"The results showed that the transient expression of POH1 increased the level of Smad3 in a dose-dependent manner in both H1299 ( Fig. 1 C) and A549 cells ( Fig. 1 D)."
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"In addition, knockdown of POH1 in H1299 cells by siRNA interference significantly decreased the protein level of Smad3, which could be reversed by the proteasome inhibitor MG132 ( Fig. 1 E)."
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"Similarly, overexpression of POH1 increased the levels of p-SMAD3 in p53 , myristoylated AKT- transformed mouse liver progenitor cells (LPC-AKT) [27] (Fig. 3f), as well as the immortalized hepatocytes LO2 (Fig. 3g)."
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