IndraLab

Statements

RNF31 binds OTULIN and CYLD. 15 / 15
| 15
sparser
"Concomitant Loss of OTULIN and CYLD Interaction with HOIP Increases M1 Ubiquitination at the TNF-RSC and Enhances TNF-Induced Gene Activation."
26670046
sparser
"HOIP interacts with both CYLD and OTULIN even in unstimulated cells."
24461064
sparser
"Mutually Exclusive Binding of CYLD and OTULIN to HOIP Causes CYLD-Selective Recruitment to SCs."
26670046
sparser
"The HOIP missense mutation affects the conserved PUB domain of HOIP ( xref ), which has recently been shown to be important for the interaction of HOIP with OTULIN and CYLD, two deubiquitinases ( xref ; xref ; xref )."
26008899
sparser
"Additionally, we used a HOIP-PUB domain point mutant (N102A), which abolishes the interaction of both OTULIN and CYLD with HOIP ( xref , xref )."
27545878
sparser
"In line with recent reports ( xref , xref , xref , xref , xref ), our data showed that prior to stimulation, both CYLD and OTULIN interacted with HOIP ( xref B–S1D)."
26670046
sparser
"In contrast to these findings, Draber et al. demonstrated that, although both OTULIN and CYLD interact with HOIP under basal conditions, OTULIN is absent from RSCs [ xref ] (Fig.  xref ) and that knock-out of OTULIN resulted in an increase of Met1-linked poly-Ub chains in the cytosol but not at TNFR1 or NOD2 RSCs [ xref ]."
33288901
sparser
"The explanation was provided by our discovery that HOIP cannot simultaneously bind OTULIN and CYLD as both require HOIP-Asn102 for binding."
26670046
sparser
"An interaction between HOIP and OTULIN or CYLD at first inspection would seem contradictory, as a futile energy-consuming cycle would exist."
27913667
sparser
"This suggested that steric hindrance may prevent simultaneous interaction of HOIP with CYLD and OTULIN."
26670046
sparser
"Interaction of OTULIN and CYLD with HOIP is mutually exclusive ( xref )."
27545878
sparser
"Together, these results show that CYLD and OTULIN interact with HOIP via the same or an overlapping site and that HOIP’s interactions with CYLD and OTULIN are mutually exclusive."
26670046
sparser
"The interaction of CYLD and OTULIN with HOIP synergistically suppresses LUBAC-mediated linear polyubiquitination and NF-κB activation."
24461064
sparser
"An interaction between HOIP and OTULIN or CYLD seems strange, since their highly specific yet counteracting activities would generate a futile energy‐consuming circle (Fig. xref B)."
26503766
sparser
"When examining the effects of absence of LUBAC activity on the constitutive interaction of HOIP with CYLD and OTULIN, we found that neither of these interactions required HOIP activity ( xref C)."
26670046