The INDRA Database

sparser

"The interaction of CYLD and OTULIN with HOIP synergistically suppresses LUBAC-mediated linear polyubiquitination and NF-κB activation."

24461064

➶

sparser

"This suggested that steric hindrance may prevent simultaneous interaction of HOIP with CYLD and OTULIN."

26670046

➶

sparser

"When examining the effects of absence of LUBAC activity on the constitutive interaction of HOIP with CYLD and OTULIN, we found that neither of these interactions required HOIP activity ( xref C)."

26670046

➶

sparser

"Together, these results show that CYLD and OTULIN interact with HOIP via the same or an overlapping site and that HOIP’s interactions with CYLD and OTULIN are mutually exclusive."

26670046

➶

sparser

"Concomitant Loss of OTULIN and CYLD Interaction with HOIP Increases M1 Ubiquitination at the TNF-RSC and Enhances TNF-Induced Gene Activation."

26670046

➶

sparser

"An interaction between HOIP and OTULIN or CYLD seems strange, since their highly specific yet counteracting activities would generate a futile energy‐consuming circle (Fig. xref B)."

26503766

➶

sparser

"In line with recent reports ( xref , xref , xref , xref , xref ), our data showed that prior to stimulation, both CYLD and OTULIN interacted with HOIP ( xref B–S1D)."

26670046

➶

sparser

"Additionally, we used a HOIP-PUB domain point mutant (N102A), which abolishes the interaction of both OTULIN and CYLD with HOIP ( xref , xref )."

27545878

➶

sparser

"An interaction between HOIP and OTULIN or CYLD at first inspection would seem contradictory, as a futile energy-consuming cycle would exist."

27913667

➶

sparser

"The HOIP missense mutation affects the conserved PUB domain of HOIP ( xref ), which has recently been shown to be important for the interaction of HOIP with OTULIN and CYLD, two deubiquitinases ( xref ; xref ; xref )."

26008899

➶

sparser

"In contrast to these findings, Draber et al. demonstrated that, although both OTULIN and CYLD interact with HOIP under basal conditions, OTULIN is absent from RSCs [ xref ] (Fig. xref ) and that knock-out of OTULIN resulted in an increase of Met1-linked poly-Ub chains in the cytosol but not at TNFR1 or NOD2 RSCs [ xref ]."

33288901

➶

sparser

"The explanation was provided by our discovery that HOIP cannot simultaneously bind OTULIN and CYLD as both require HOIP-Asn102 for binding."

26670046

➶

sparser

"Mutually Exclusive Binding of CYLD and OTULIN to HOIP Causes CYLD-Selective Recruitment to SCs."

26670046

➶

sparser

"Interaction of OTULIN and CYLD with HOIP is mutually exclusive ( xref )."