IndraLab

Statements

USP17L2 activates Snail1. 5 / 5
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"However, knockdown of Dub3 blocked the Snail1 stabilization effect mediated by the knockdown of either beta-TRCP1 or FBXL14 (lanes 4 and 5, XREF_FIG), indicating that Dub3 is a critical factor controlling Snail1 stability."
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"Together, these data indicate that Dub3 can induce EMT (luminal to basal like phenotype conversion) by stabilizing Snail1 in breast cancer cells."
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"Dub3 expression induced Snail1 stabilization as well as downregulation of E-cadherin and oestrogen receptor alpha (ERalpha) in these cells (XREF_FIG)."
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"Expression of the WT-Dub3, but not CS-Dub3, blocked Snail1 degradation mediated by these two ligases."
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"DUB3 mediated Snail1 stabilization is induced and activated by cytokine IL-6 [XREF_BIBR] in a CDK4/6 dependent manner [XREF_BIBR]."
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