IndraLab

Statements

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"OTUB1 Promotes Progression and Proliferation of Prostate Cancer via Deubiquitinating and Stabling Cyclin E1 Background : Prostate cancer ( PCa ) is currently the most common cancer among males worldwide ."
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"Discussion In our research , we found that the expression levels of OTUB1 are up-regulated in PCa , OTUB1 could promote the proliferation and progression of PCa via deubiquitinating and stabling the expression of Cyclin E1 protein ."
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"We finally determined that OTUB1 promotes the proliferation and progression of PCa via deubiquitinating and stabling Cyclin E1 ."
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"Although we have found that otub1 promoted the proliferation and progression of PCa via mediating and stabling Cyclin E1 , in which one ubiquitination enzyme directly causing to the ubiquitination degradation of Cyclin E1 remains unclear , and the manner of OTUB1 regulating the expression of Cyclin E1 directly or indirectly are still yet not determined ."
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"So far , we have a lot of evidence to identify the hypothesis that OTUB1 promotes the progression and proliferation of prostate cancer via mediating and stabling Cyclin E1 ."
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"These results suggested that OTUB1 might promote the proliferation of PCa via mediating Cyclin E1 ."
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"Conclusions : Our findings reveal the critical role of OTUB1 in PCa , and OTUB1 promotes the proliferation and progression of PCa via deubiquitinating and stabilizing Cyclin E1 ."
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"OTUB1 promotes prostate cancer [ 12 ] ."
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"And we further found that OTUB1 promoted the progression of PCa via regulating the stability and interacting with Cyclin E1 ."
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"Therefore , this research preliminarily proposed that OTUB1 could promote the progression and proliferation of PCa via regulating the expression of Cyclin E1 , thus the specific internal mechanism will become the main work and direction in the next step ."
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"OTUB1 Promotes Progression and Proliferation of Prostate Cancer via Deubiquitinating and Stabling Cyclin E1 ."
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