IndraLab
Statements
"We show that pkcalpha is likely to be directly involved in ser24 phosphorylation...Using Ser24asp irs-1 mutants to mimic the phosphorylated residue, we demonstrate that the phosphorylation status of ser24 does play an important role in regulating phosphoinositide binding to, and the intracellular localization of, the irs1-ph domain, which can ultimately impinge on insulin-stimulated glucose uptake"