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Glutamate(2-) dephosphorylates KCNB1. 4 / 4
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"Because the glutamine-glutamate cycle is also directly linked to the citric acid cycle ( xref ), the cessation of the cycle would also affect the glutamate uptake of astrocytes ( xref ; xref ) which is also implicated in our results that MSO induced the glutamate-dependent Kv2.1 dephosphorylation."
18716211
sparser
"Glutamate produces a Ca 2+ -dependent dephosphorylation of Kv2.1 channels, which disrupts channel clusters and increases mean open channel probability and conductance (Murakoshi et al. xref ; Misonou et al. xref )."
20396973
sparser
"Taken together with the preliminary finding of another group that a non-selective inhibitor of glutamate transporter, TBOA ( xref ), induces Kv2.1 dephosphorylation in organotypic hippocampal slice culture ( xref ), we hypothesized that the dysfunction of glutamate transporters in astrocytes during ischemia results in the accumulation of extracellular glutamate and glutamate-induced Kv2.1 modulation."
18716211
sparser
"Our finding shows that inhibiting GLT-1 function with DHK and TBOA is sufficient to cause glutamate-dependent Kv2.1 dephosphorylation in vitro, although this does not exclude the possibility of glutamate release from astrocytes during ischemia ( xref ; xref ; xref ; xref ; xref )."
18716211