IndraLab

Statements

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"In the present study, we report that 14-3-3 proteins directly bind to the intracellular loop of TRESK and control the kinetics of the calcium-dependent regulation of the channel."
18397886
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"The association of 14-3-3 to TRESK depends on the phosphorylation of a serine ( underlined , see the above sequence) in the channel xref ."
24830385
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"The pull-down of tubulin was reduced by the binding of 14-3-3 to TRESK loop ( xref , lane 3 , red asterisk ), compared to the bait without the adaptor protein ( lane 2 )."
24830385
sparser
"The adaptor protein 14-3-3 can also bind directly to TRESK, provided that the second serine in the RSN S CPE motif (S264 in the mouse and S252 in the human channel) is phosphorylated ( Czirják et al.,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22115960
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"However, this effect was demonstrated to be independent from the direct interaction between TRESK and 14-3-3 ( Czirják and Enyedi, 2010 )."
22115960
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"This suggests that 14-3-3 inhibited the kinase phosphorylating the regulatory cluster of Ser-274, Ser-276, and Ser-279, independently of the direct interaction between TRESK and 14-3-3."
20215114
sparser
"The binding of 14-3-3 to TRESK-loop-His 8 is in good accordance with our previous results that 14-3-3 functionally interacts with TRESK, if the channel is phosphorylated by PKA xref , xref ."
24830385
sparser
"Serine 264 and the direct interaction of 14-3-3 with TRESK were not indispensable for the effect of MARK2, suggesting that this kinase acted via the S274/276/279 cluster."
22145024