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Serotonin inhibits KCNMA1. 3 / 3
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"Thus, the present study determined whether the cerebral vasculature of FHH rat exhibits impaired vasoconstrictor response to 5-HT that is associated with an inability to inhibit BK channel activity relative to FHH.1 BN rats, and if blockade of the BK channel can restore the vasoconstrictor response to 5-HT."
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"5-HT in the presence of 4-AP decreased the residual BK channel current significantly in FHH.1 BN rats but not in FHH rats (46 vs. 6%) (XREF_FIG, A and B)."
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"5-HT (3 muM) decreased BK channel and spontaneous transient outward currents in VSMCs isolated from FHH.1 BN but had no effect in FHH rats."
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