IndraLab

Statements

KCNMA1 inhibits CXCL8. 5 / 5
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"In addition, SLO at subcytotoxic concentrations blocked neutrophil degranulation, interleukin-8 secretion and responsiveness, and elaboration of DNA based neutrophil extracellular traps, cumulatively supporting a key role for SLO in GAS resistance to immediate neutrophil killing."
26635795
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"Thus, SLO production by GAS impairs neutrophil IL-8 release and their activation and migratory responses to the chemokine."
26635795
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"SLO blocked neutrophil degranulation, IL-8 secretion and responsiveness, and elaboration of DNA based NETs, cumulatively supporting a key role for SLO as a modulator of PMNs ' functions. ""
30774411
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"Our findings show that SLO prevents the release of IL-8 and elastase from neutrophils and blocks the formation of NETs."
26635795
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"The differentiated THP-1 cells secreted IL-8 in response to infection by Deltaslo, Deltanga, and Nga R289K and G330D mutants but not JRS4 wild-type or Deltanga : : nga strains (XREF_FIG), which suggests that SLO and Nga may inhibit IL-8 secretion by macrophages."
33563838