IndraLab

Statements


RAF1 phosphorylated on S289 is active. 2 / 2
2 |

"Erk-induced raf-1 phosphorylation sustains raf-1 kinase activity furthermore, using direct in vitro phosphorylation we show that these sites are direct targets of erk-1 and using phosphospecific antibodies developed against one of the sites, s296, show that these sites are physiological phosphorylation sites induced in vivo after mitogen stimulation."

"Erk-induced raf-1 phosphorylation sustains raf-1 kinase activity furthermore, using direct in vitro phosphorylation we show that these sites are direct targets of erk-1 and using phosphospecific antibodies developed against one of the sites, s296, show that these sites are physiological phosphorylation sites induced in vivo after mitogen stimulation."