EGF binds EGFR, ERBB4, and EREG. 1 / 1
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"Each member has distinct binding affinities to different ligands that allows the classification of ligands into three groups: in the first group, EGF, transforming growth factor- α (TGF- α ) and amphiregulin (AREG) specifically bind to EGFR; in the second group, betacellulin, heparin-binding EGF (HB-EGF) and epiregulin bind to both EGFR and ERBB4; the third class include neuregulins (NRGs) that bind to either only ERBB4 (NRG3 and NRG4) or both ERBB3 and ERBB4 (NRG1 and NRG2)."