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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

EGF binds EGFR, ERBB4, and EREG. 1 / 1

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"Each member has distinct binding affinities to different ligands that allows the classification of ligands into three groups: in the first group, EGF, transforming growth factor- α (TGF- α ) and amphiregulin (AREG) specifically bind to EGFR; in the second group, betacellulin, heparin-binding EGF (HB-EGF) and epiregulin bind to both EGFR and ERBB4; the third class include neuregulins (NRGs) that bind to either only ERBB4 (NRG3 and NRG4) or both ERBB3 and ERBB4 (NRG1 and NRG2)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...