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RPS6KB1 phosphorylates IRS1 on S1101. 28 / 28
1 1 1 | 10 13 2
reach
"Western blot images showed that S6K1-dependent phosphorylation of IRS-1 on S307 and S1101, but not IRS-1 itself, were decreased in miR-200b- and miR-200c-transfected SH-SY5Y cells (Fig 5)."
29738527
sparser
"IRS1 phosphorylation at S1101 by S6K1 could play an important role in metabolic stress mechanisms and contribute to the development of IR; this phosphorylation has been cataloged as an early event in the desensitization of insulin signaling in pathological contexts [ xref , xref ]."
36224569
sparser
"S6K1 phosphorylates IRS-1 at serine 1101 [ xref , xref ] and disrupts its interaction with PI3K, leading to poor AKT activation upon insulin stimulation [ xref ]."
30296358
biopax:phosphositeplus
No evidence text available
sparser
"S6K1 kinase phosphorylates IRS1 at serine 1101 (S1101), inhibiting its function and impairing insulin signaling [ xref ]."
36224569
sparser
"We observed that S6K1-dependent phosphorylation of IRS1 on S307 and S1101 was diminished in SH-SY5Y cells treated with miR-200b and miR-200c."
29738527
reach
"S6K1 phosphorylates IRS-1 at Ser 1101 and suppresses PI3K activation."
25379019
sparser
"mTOR phosphorylates and activates S6K1, which then phosphorylates IRS-1 S1101 , leading to poor activation of its downstream PI-3 kinase as evidenced by weak binding of the PI-3 kinase to IRS-1 and weak AKT phosphorylation upon insulin stimulation [ xref , xref ]."
32998286
sparser
"Western blot images showed that S6K1-dependent phosphorylation of IRS-1 on S307 and S1101, but not IRS-1 itself, were decreased in miR-200b- and miR-200c-transfected SH-SY5Y cells ( xref )."
29738527
signor
"Nevertheless, s6k1-deficient mice remain sensitive to insulin owing to the apparent loss of a negative feedback loop from s6k1 to insulin receptor substrate 1 (irs1), which blunts s307 and s636/s639 phosphorylation; thus under conditions of nutrient satiation s6k1 negatively regulates insulin."
15306821
reach
"S6K1 phosphorylates insulin receptor substrate 1 (IRS-1) at Ser1101 and Ser302."
26926384
reach
"In addition, S6K1 phosphorylates IRS-1 at Ser 1101 and suppresses IGF-1 receptor mediated activation of the PI3K pathway XREF_BIBR."
25379019
sparser
"S6K1 also increased IRS1 Ser1101 phosphorylation in CHO-Tau35 cells compared to CHO-FL cells (Fig. xref c, d)."
30606258
sparser
"Tremblay et al. ( xref ) identified in an in vitro model that S6K1 directly phosphorylates IRS1 Ser‐1101 resulting in suppression of IRS1 tyrosine and Akt phosphorylation, and further, insulin resistance (Tremblay et al.,  xref )."
33038072
sparser
"S6K1 phosphorylates IRS-1 at Ser-1101 and suppresses PI3K activation."
25379019
biopax:netpath
No evidence text available
18952604
reach
"(2007) identified in an in vitro model that S6K1 directly phosphorylates IRS1 Ser 1101 resulting in suppression of IRS1 tyrosine and Akt phosphorylation, and further, insulin resistance (Tremblay etal.,2007)."
33038072
sparser
"Infusion of amino acids into humans leads to the activation of S6K1 phosphorylation of IRS-1 Ser 1101 , a reduction of IRS-1 function and insulin resistance in skeletal muscle [ xref ]."
26474286
sparser
"IRS-1 S1101 phosphorylation by S6K1 leads to its weak binding to the p85 subunit of PI-3 kinase and poor activation [ xref , xref ]."
32998286
reach
"It is well established that S6K1 phosphorylates IRS-1 S1101 and suppresses the IGF-1 receptor mediated activation of the PI3K pathway (XREF_FIG) XREF_BIBR."
25379019
rlimsp
"P70 S6 kinase (S6K1) is a serine/threonine kinase that phosphorylates the insulin receptor substrate-1 (IRS-1) at serine 1101 and desensitizes insulin receptor signaling."
29496905
reach
"Ribosomal protein S6 kinase beta-1 (S6K1) phosphorylation of insulin receptor substrate 1 (IRS-1) at S1101 blocks its interaction with PI3K, leading to insulin resistance."
27889207
reach
"Here we show that S6K1 directly phosphorylates IRS-1 Ser 1101 in vitro in the C-terminal domain of the protein and that mutation of this site largely blocks the ability of amino acids to suppress IRS-1 tyrosine and Akt phosphorylation."
17709744
reach
"We observed that S6K1-dependent phosphorylation of IRS1 on S307 and S1101 was diminished in SH-SY5Y cells treated with miR-200b and miR-200c.The oAβ leads to additional generation of oAβ resulted from abnormal autophagosome accumulation via inhibition of mTOR pathway [17]."
29738527
reach
"Infusion of amino acids into humans leads to the activation of S6K1 phosphorylation of IRS-1 Ser 1101, a reduction of IRS-1 function and insulin resistance in skeletal muscle [XREF_BIBR]."
26474286
rlimsp
"Here we show that S6K1 directly phosphorylates IRS-1 Ser-1101 in vitro in the C-terminal domain of the protein and that mutation of this site largely blocks the ability of amino acids to suppress IRS-1 tyrosine and Akt phosphorylation."
17709744
sparser
"In addition, S6K1 phosphorylates IRS-1 at Ser-1101 and suppresses IGF-1 receptor–mediated activation of the PI3K pathway xref ."
25379019
sparser
"It is well established that S6K1 phosphorylates IRS-1 S1101 and suppresses the IGF-1 receptor–mediated activation of the PI3K pathway ( xref ) xref ."
25379019