IndraLab

Statements

KCNMA1 activates Ala-Pro. 8 / 8
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"Thus, in hippocampal pyramidal cells, the inactivating BK channel, which likely results from slo1+ BK beta2 subunits, promotes frequency dependent AP broadening along a train of spikes."
22584144
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"This analysis thus further confirms that abnormally elevated neurotransmitter release and STP caused by the absence of FMRP are mediated by BK channel dependent, excessive AP broadening that occurs in the axons in the vicinity of presynaptic terminals."
23439122
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"Computational modeling of adrenal chromaffin cells supports the concept that BK channel sharpening of APs and larger fAHP can theoretically promote a higher AP frequency by reducing sodium channel inactivation."
25311634
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"These results were consistent with vesiculation as the mechanism for SLO induction of AP release."
7832771
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"Application of BK channel blockers reduces the fAHP, slows AP repolarization, and produces prolonged spikes in PCs."
28948109
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"It is therefore a reasonable expectation that local BK channel mediated changes in AP shape will be reflected in similar changes in somal spikes."
29978045
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"This result suggested that the released AP contained an intact GPI anchor, and thus both proteolysis and anchor degradation by anchor specific hydrolases, including GPI-PLD, as the potential mechanisms for SLO mediated AP release were ruled out."
7832771
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"Based on differential sensitivity to EGTA and BAPTA, localized Ca 2+ signaling around VGCCs is thought to drive BK channel activation that mediates AP repolarization and fAHPs."
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