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HAX1 binds KCNC3. 17 / 17
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"Our data indicate that Hax-1 interacts with the C-terminal domain of Kv3.3 and becomes enriched at the cell cortex."
26997484
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"Here, the authors show that the known Kv3.3 channel complex with Hax1, which affects spinal cerebellar ataxia, regulates the enzyme Tank Binding Kinase 1, modulating survival of cerebellar neurons."
33741962
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"Accordingly, the binding of Hax-1 to Kv3.3 directly triggers the formation of a stable channel-associated subcortical actin cytoskeleton that acts to prevent inactivation of Kv3.3 during depolarization [8]."
29949095
sparser
"These findings are consistent with the hypothesis that TBK1-dependent association of Kv3.3 with Hax-1 regulates its rate of inactivation (Fig.  xref ) and the finding that inactivation of G592R Kv3.3 channels is slower than that of wild type channels (Fig.  xref )."
33741962
sparser
"Accordingly, the binding of Hax-1 to Kv3.3 directly triggers the formation of a stable channel-associated subcortical actin cytoskeleton that acts to prevent inactivation of Kv3.3 during depolarization [ xref ]."
29949095
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"Moreover, effects of cortical Kv3.3-Hax-1 interactions are likely to be abolished in disease-causing mutations that prevent trafficking of Kv3.3 to the plasma membrane ( Gallego-Iradi et al., 2014 )."
26997484
sparser
"Because the binding of Hax-1 to Kv3.3 prevents rapid inactivation of the channels xref , we tested the effects of the TBK1 inhibitor on the characteristics of Kv3.3 currents using the whole-cell patch-clamp technique."
33741962
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"The interaction between Kv3.3 and Hax-1 provides potential links between SCA13 mutations and degeneration of neurons such as cerebellar Purkinje cells."
26997484
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"The effects of Kv3.3 on the actin cytoskeleton are mediated by the binding of the cytoplasmic C-terminus of Kv3.3 to Hax-1, an anti-apoptotic protein that regulates actin nucleation through Arp2/3."
26997484
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"A recent study has shown that the cytoplasmic C-terminal domain of Kv3.3 channels binds Hax-1, an anti-apoptotic protein required for the survival of cerebellar neurons [8]."
29949095
sparser
"The binding of Hax-1 to Kv3.3 is also required to prevent the channel from inactivating rapidly during sustained depolarization xref ."
33741962
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"The Kv3.3 channel directly binds Hax-1, a cell survival protein."
34820911
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"To probe further how an abnormal interaction between Kv3.3 and Hax-1 leads to cerebellar degeneration, we used CRISPR/Cas9 gene editing to generate homozygous G592R Kv3.3 knock-in mice (Supplementary Fig.  xref )."
33741962
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"TBK1 activity is required for the binding of Kv3.3 to its auxiliary subunit Hax-1, which prevents channel inactivation with depolarization."
33741962
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"Although Hax-1 binds G592R Kv3.3, its ability to trigger Arp2/3-dependent actin nucleation and to link N-type inactivation to the cytoskeleton is impaired when bound to this mutant channel."
26997484
sparser
"Thus, the interaction of Kv3.3 with Hax-1 leads to formation of a stable subcortical actin cytoskeleton under the plasma membrane where Kv3.3 is expressed."
33741962
sparser
"The binding of Hax-1 to the C-terminus of Kv3.3 channels also prevents rapid inactivation of the channel during depolarization."
33741962