IndraLab

Statements

reach
"The NOD-like protein, NLRX1 and the globular domain of complement 1q receptor (gc1qR) interact with components of oxidative phosphorylation and increase ROS production (Tattoli et al. 2008; Saha et al. 2013) whereas the cytochrome c oxidase complex subunit COX5B, coordinates with the autophagy pathway through autophagy-related gene 5 (ATG5), to suppress MAVS signaling and decrease ROSproduction (Zhao et al. 2012)."
| PMC
reach
"Induction of ROS by rotenone induced mitophagy and led to degradation of MAVS in both HEK293T WT and Mavs-(M2-6L) cells; while reduction of ROS by antioxidant propyl gallate (PG) only accumulated MAVS-(M2-6L) in Mavs-(M2-6L) cells (XREF_FIG), suggesting that spontaneously aggregated MAVS was degraded by ROS induced mitophagy."
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reach
"Besides, TRX2 inhibits the formation of VISA aggregates by repressing reactive oxygen species (ROS) production, thereby disrupting the assembly of VISA complex."
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