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AKT decreases the amount of ESR1. 8 / 8
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"The constitutively activated myristylated Akt reduced ERalpha expression, whereas agents that negatively affect the PI3K and Akt pathway, i.e., wortmannin, celecoxib, and the green tea polyphenol epigallocatechin-3 gallate, induced ERalpha."
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"Activation of the PI3K and AKT and the p42/44 mitogen activated protein kinases (MAPK) pathways by these receptors, in turn, downregulates the expression of ER and PR."
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"In agreement with our data, Guo and colleagues reported that constitutively active AKT reduces ERalpha expression, whereas AKT inhibition increases ERalpha levels [XREF_BIBR]."
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"Further, AZD5363 treatment increased ER protein levels in the HBCx-3 xenografts [see Additional file XREF_SUPPLEMENTARY, Figure S5D], suggesting that active AKT represses ER expression both in vitro and in vivo."
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"PI3K and AKT pathway activation has been associated with increased ER transcriptional activity and reduced ER expression in MCF-7 cells."
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"Guo et al. suggested that activated Akt reduces ER expression by inactivation of FoxO3a 20 and in the present study Akt2 negatively correlated to ER.van Agthoven et al. showed that lymph node negative[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Inhibition of the PI3K and AKT pathway using AZD5363 or BKM120 induced ERalpha expression."
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"Activation of AKT alone is sufficient for PI3-kinase-mediated destabilisation of ERalpha as a constitutively active AKT (CA-AKT) but not kinase-dead AKT (KD-AKT) reduced ERalpha levels (XREF_FIG)."
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