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AKT decreases the amount of ESR1. 5 / 5
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"Inhibition of the PI3K and AKT pathway using AZD5363 or BKM120 induced ERalpha expression."
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"In agreement with our data, Guo and colleagues reported that constitutively active AKT reduces ERalpha expression, whereas AKT inhibition increases ERalpha levels [XREF_BIBR]."
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"Activation of AKT alone is sufficient for PI3-kinase-mediated destabilisation of ERalpha as a constitutively active AKT (CA-AKT) but not kinase-dead AKT (KD-AKT) reduced ERalpha levels (XREF_FIG)."
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"The constitutively activated myristylated Akt reduced ERalpha expression, whereas agents that negatively affect the PI3K and Akt pathway, i.e., wortmannin, celecoxib, and the green tea polyphenol epigallocatechin-3 gallate, induced ERalpha."
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"Of note, MK‐2206 exhibited the most prominent enhancement of ESR1 expression in CCL23‐overexpressed HepG2 cells (Figure 5E), consistent with the previous observation that the activation of AKT could inactivate FOXO3A, leading to reduced transcription of ESR1 (encoding ERα) in breast cancer cells.24, 25 In line with these data, interference of CCL23 increased AKT phosphorylation and decreased ESR1 protein level, whereas inhibition of AKT by MK‐2206 in siCCL23‐treated HepG2 cells rescued the expression of ESR1 protein (Figure 5F)."
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