IndraLab

Statements

USP22 deubiquitinates EGFR. 4 / 4
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"Similarly, shRNA knockdown of USP22 resulted in accumulated Ubn-EGFR, which further confirmed that USP22 antagonizes EGFR ubiquitination."
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"In this model, late endosome localized USP22 deubiquitinates EGFR and impedes sorting of EGFR to the lysosome, thus sustaining the trafficking of EGFR to the plasma membrane (Figs. 6 and 9)."
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"Concurrently, USP22 deubiquitinates EGFR on late endosomes, enhancing its recycling and the sustained activation of various downstream signaling pathways upon EGF stimulation [191]."
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"Additionally, <span class="match term0">USP22</span> sustained the activation of multiple <span class="match term1">EGFR</span> downstream signaling pathways, including STAT3, AKT/mTOR and MEK/ERK pathways, in lung ADC cell lines H1975 and PC9."
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