IndraLab

Statements

BAP1 deubiquitinates HCFC1. 7 / 7
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"HCF-1 is modified with ubiquitin in vivo, and ectopic studies suggest BAP1 deubiquitinates HCF-1."
21484256
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"It has been proposed that BAP1 may modulate cell proliferation by deubiquitylating the transcriptional regulator HCF1."
32690542
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"BAP1 also interacts with and deubiquitinates the transcriptional regulator host cell factor 1 (HCF1)."
31151962
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"The massive increase of BAP1 expression with tumor cell proliferation was expected, as BAP1 regulates cell proliferation via deubiquitination of its target protein host cell factor-1 (HCF1), which plays a critical role at multiple stages of the cell cycle [55, 56]."
31903168
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"The tumor suppressor BAP1 associates with ASXL1/2 to form the core Polycomb complex PR-DUB, which catalyzes the removal of mono-ubiquitin from several substrates including histone H2A. This complex also mediates the poly-deubiquitination of HCFC1, OGT and PCG1-α, preventing them from proteasomal degradation."
29069806
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"It has been proposed that ubiquitylation of HCF1 blocks E2F responsive promoter activity, and that HCF1 deubiquitylation by BAP1 would remove this inhibition and promote cell proliferation 33."
23550303
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"SETD2 is a histone H3 lysine 36 (H3K36) methyltransferase that regulates mRNA splicing and transcription elongation; BAP1 interacts with and deubiquitinates host cell factor-1 (HCF-1), a transcription co-activator, that regulates cell proliferation; and KDM5C a histone 3 trimethyl-lysine 4 (H3K4Me3) demethylase that erase active transcription marks."
23036577