IndraLab

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BAP1 deubiquitinates HCFC1. 13 / 13
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"Furthermore, BAP1 also deubiquitinates its main interacting protein, host cell factor 1 (HCF-1) [107] ."
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"Machida et al. reported that HCFC1 was deubiquitinated by the deubiquitinating enzyme BRCA1-associated protein 1 to regulate cell divisions and proliferation 39."
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"10 Deubiquitination of HCF1 and H2Aub by BAP1 promotes their association with EF2, YY-1, and FoxK2, which regulate cell-cycle progression, cell proliferation and cell-cycle control."
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"It has been proposed that BAP1 may modulate cell proliferation by deubiquitylating the transcriptional regulator HCF1."
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"BAP1 also promoted cell proliferation through directly interacting and deubiquitinating host cell factor-1 (HCF-1) [12] ."
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"HCF-1 is modified with ubiquitin in vivo, and ectopic studies suggest BAP1 deubiquitinates HCF-1."
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"BAP1 also interacts with and deubiquitinates the transcriptional regulator host cell factor 1 (HCF1)."
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"Moreover, BAP1 modulates histone H2A and HCFC1 deubiquitination and regulates transcription, cell cycle and growth, response to DNA damage and chromatin dynamics."
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"BAP1 can deubiquitinate HCF-1 and is crucial for HCF-1 activity ( Zhou et al., 2013 )."
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"It has been proposed that ubiquitylation of HCF1 blocks E2F responsive promoter activity, and that HCF1 deubiquitylation by BAP1 would remove this inhibition and promote cell proliferation 33."
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"The massive increase of BAP1 expression with tumor cell proliferation was expected, as BAP1 regulates cell proliferation via deubiquitination of its target protein host cell factor-1 (HCF1), which plays a critical role at multiple stages of the cell cycle [55, 56]."
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"SETD2 is a histone H3 lysine 36 (H3K36) methyltransferase that regulates mRNA splicing and transcription elongation; BAP1 interacts with and deubiquitinates host cell factor-1 (HCF-1), a transcription co-activator, that regulates cell proliferation; and KDM5C a histone 3 trimethyl-lysine 4 (H3K4Me3) demethylase that erase active transcription marks."
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"The tumor suppressor <span class="match term0">BAP1</span> associates with ASXL1/2 to form the core Polycomb complex PR-DUB, which catalyzes the removal of mono-ubiquitin from several substrates including histone H2A. This complex also mediates the poly-deubiquitination of <span class="match term1">HCFC1</span>, OGT and PCG1-alpha, preventing them from proteasomal degradation."
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