IndraLab

Statements

CDK4 phosphorylates RB1 on S795. 12 / 12
1 1 2 | 3 3 2
hprd
No evidence text available
19664994
hprd
No evidence text available
9190208
biopax:phosphositeplus
No evidence text available
reach
"Notably both Cdk2 and Cdk4 kinase complexes phosphorylate, during the G 1 to S transition, pRb protein on Ser 795."
19262748
reach
"Furthermore, there is no direct evidence indicating that the suppression of cdk4 protein induced by TGF-beta1 leads to inhibition of pRb phosphorylation at Ser795, although pRb reportedly is phosphory[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10210318
rlimsp
"The differential effects of phosphorylation on pRb function coincide with modification of distinct sets of sites. Serine 795 is phosphorylated efficiently by Cdk4, even in the absence of an intact LXCXE motif in cyclin D, but not by Cdk2 or Cdk3."
9190208
sparser
"Furthermore, there is no direct evidence indicating that the suppression of cdk4 protein induced by TGF-β1 leads to inhibition of pRb phosphorylation at Ser795, although pRb reportedly is phosphorylat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10210318
reach
"Sequential phosphorylation of pRb by cyclin dependent kinases including CDK4 regulates S-phase of cells [XREF_BIBR], Cyclin D1 and CDK4 complex phosphorylates pRb at Ser 795 residue to induce DNA synthesis [XREF_BIBR], We directly determined the role of miR-21-regulated cyclin D1 in renal cancer cell proliferation."
23981302
signor
"Cyclin d1 is known to activate cdk4, which then phosphorylates the rb protein, leading to cell cycle progression."
23336272
rlimsp
"Phosphorylation of serines 608/612 inhibits binding of E2F-1 to RB. In Nalm-6 acute lymphoblastic leukemia extracts, serine 608 is phosphorylated by CDK4/6 complexes but not by CDK2. We reasoned that phosphorylation of serines 608/612 by redundant CDKs could accelerate phospho group formation and determined which G1 CDK contributes to serine 612 phosphorylation. Here, we report that CDK4 complexes from Nalm-6 extracts phosphorylated in vitro the CDK2-preferred serine 612, which was inhibited by p16INK4a, and fascaplysin. In contrast, serine 780 and serine 795 were efficiently phosphorylated by CDK4 but not by CDK2."
16936279
sparser
"While Cdk4-cyclin D efficiently and specifically phosphorylates pRb on Ser780 and Ser795, Cdk2-cyclin A/E does not."
19551155
sparser
"With CCND1 stimulation and CDKN2A inhibition, CDK4 phosphorylates the tumor suppressor retinoblastoma protein (RB) at serine780 and serine795 [ xref ], allowing pRB to activate the transcriptional factor E2F [ xref ]."
27708221