IndraLab

Statements

NOS3 activates RAS. 9 / 9
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"We speculate that oncogenic Ras activates ROS production by NADPH oxidase, which further activates other Ras isoforms in a positive feedback loop similar to that seen with eNOS mediated activation of wild-type Ras isoforms."
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"In turn, eNOS activation by AKT enhances the nitrosylation and activation of the endogenous wild-type Ras protein, thus promoting tumor growth."
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"Moreover, eNOS enhances the nitrosylation and activation of endogenous wild-type Ras proteins, which are required throughout tumorigenesis."
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"Furthermore, inhibition of eNOS with the NOS inhibitor L-NAME blocked NMDA receptor activation of Ras."
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"Akt phosphorylation and activation of endothelial NOS (eNOS) stimulates RNS dependent oxidation or S nitrosylation of Cys 118 of Ras resulting in cytoprotective signaling through Akt."
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"In was found that blocking the eNOS phosphorylation could inhibits tumorigenesis, while overexpression of eNOS enhanced the nitrosylation and activation of Ras proteins in vitro and vivo (Lim et al., 2008)."
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"We have found that eNOS derived NO positively regulates Ras and ERK activation in T cells stimulated with antigen on antigen presenting cells (APCs)."
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"Moreover, eNOS enhances the nitrosylation and activation of endogenous wild-type Ras proteins, which are required throughout tumorigenesis."
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"Is eNOS mediated Ras activation important for a subset of Ras mediated T-cell functions, such as clonal expansion or differentiation, and is this activation mechanism important in pathological settings such as lupus?"
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