IndraLab

Statements

TSC2 decreases the amount of TSC2. 16 / 16
| 16
reach
"Akt-dependent phosphorylation of TSC2 inhibits the function of TSC1–TSC2 complex by triggering release of TSC2 from TSC1 at an intracellular membrane [33] ."
23517912
reach
"First, western blotting validated that the expression of TSC2 was effectively decreased by TSC2 targeted shRNA (XREF_FIG)."
34395438
reach
"In addition, this reaction could happened with the primary amine of free LAM which decreases the free amount of LAM, thus increasing EE%."
39901331
reach
"Several mechanisms could explain this finding, including the downregulation of LAM expression or the inhibition of LprG activity to limit LAM transport, both of which would be expected to limit LAM expression on the Mtb membrane and, presumably, LAM expression of EVs secreted by Mtb-infected cells during LTBI."
35986185
reach
"A previous study in smooth muscle like cells from a patient with tuberous sclerosis showed that epigenetic regulation of the TSC2 promoter through methylation represses TSC2 expression."
27048565
reach
"While we find that activation of N is sufficient and required for repression of TSC2 protein in EBs in vivo, our S2 studies indicate that the turnover rate of the TSC2 protein also has to be increased to achieve rapid reduction of TSC2 levels."
23144631
reach
"It has been shown that an epigenetic alteration of TSC2 can cause the loss of tuberin in TSC cells."
29308833
reach
"LAM and TSC cells bear a germline mutation in exon 21 of TSC2 and do not express tuberin because of an epigenetic silencing of the TSC2 second allele that confirms our previously published evidence that an epigenetic alteration of TSC2 can cause the loss of tuberin in TSC cells [XREF_BIBR]."
24606538
reach
"Inhibition of tuberin expression by Tsc2 antisense greatly reduces the ability of TGF-beta to transcriptionally regulate p21 (CIP), p27 (KIP), and cyclin A leading to an abrogation of the antiproliferative effects of TGF-beta1."
15066998
reach
"The TSC2 shRNA strongly reduced endogenous TSC2 expression in all MEFs (XREF_FIG)."
19838215
reach
"Moreover, transfection of TSC2 and tuberin siRNA into PC-3 cells inhibited the expression of tuberin, mildly increased the basal phosphorylation level and only marginally counteracted curcumin mediated inhibition (XREF_FIG), while showed no effect on the basal level or curcumin mediated inhibition of the phosphorylation of Akt."
18790744
reach
"TSC2 RNAi significantly decreased endogenous TSC2 protein levels, but had no effect on the unrelated protein MEK2."
14651849
reach
"In addition, previous studies in human neuroblastoma cell lines have demonstrated that tuberin AS-constructs reduce tuberin expression and alter cell cycle dynamics."
11583980
reach
"After TSC2 siRNA treatment for 24 h, Western blot analysis showed that transfection of TSC2 siRNA-1, TSC2 siRNA-2, and TSC2 siRNA-3 significantly reduced the expression of TSC2 in podocytes cultured with high glucose (P < 0.05)."
35799948
reach
"Su (H)-mediated transcriptional repression of gigas and Tsc2 was thus a plausible mechanism for N induced repression of TSC2 expression in EBs."
23144631
reach
"Compared with IL-1β + QUE-8 + Sh-NC group, the expression of TSC2 in the IL-1β + QUE-8 + sh-TSC2 group was remarkably reduced, indicating that sh-TSC2 could down-regulate the expression of TSC2."
35093450