IndraLab

Statements

UCHL5 binds SMAD7. 19 / 21
1 2 | 6 10
sparser
"It has been reported that UCHL5 and Smad7 formed a stable complex and stabilized TβRI xref ."
27604640
sparser
"UCHL5 binds to Smad7 and deubiquitinates the Smad7-Smurf1/Smurf2 (E3 ubiquitin ligase)-polyubiquitinated TGF-βR1 complex [4,10] ."
23500140
sparser
"UCH37 also interacts with SMAD7 through the SMAD7 N-terminal domain (1–260 aa), and not via the PY motif, a region that mediates SMAD7’s binding to SMURF (Wicks et al., xref )."
24756567
sparser
"However, ubiquitination is reversed by the deubiquitinating enzyme UCH37, which competitively binds Smad7 ( xref )."
35095928
reach
"UCH37 binds strongly to Smad7 and weakly to Smad2 and Smad3."
27155333
reach
"UCHL5 binds to Smad7 and deubiquitinates the Smad7-Smurf1/Smurf2 (E3 ubiquitin ligase)-polyubiquitinated TGF-βR1 complex [4,10] ."
23500140
reach
"The deubiquitinating enzyme (DUB) UCH37 can bind to Smad7."
22752156
sparser
"Endogenous Smad7 and UCH37 formed a stable complex in U4A/JAK1 cells, and FLAG-Smad7 co-immunoprecipitated with HA-UCH37 in transfected HEK-293 cells."
16027725
biogrid
No evidence text available
16027725
biogrid
No evidence text available
16027725
sparser
"Previously, we reported a novel interaction between inhibitory Smad7 and UCH37, and showed that Smad7 acts as an adaptor that recruits UCH37 to the type I TGFβ receptor to reverse Smurf-mediated ubiqu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21187158
sparser
"UCH37 is associated with SMAD7 and influences TGF-β-mediated transcription during the early phase of TGF-β receptor activation."
33158118
sparser
"UCH37 binds strongly to Smad7 and weakly to Smad2 and Smad3."
27155333
reach
"Wicks and colleagues reported UCH37 interacts with Smad7 to control TGF-beta and Smad signaling activity, suggesting that UCH37 mediated deubiquitination might contribute to tumorigenesis."
33585209
reach
"Previously, we reported a novel interaction between inhibitory Smad7 and UCH37, and showed that Smad7 acts as an adaptor that recruits UCH37 to the type I TGFβ receptor to reverse Smurf-mediated ubiqu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21187158
reach
"In this process, UCH37 competes with Smad ubiquitination regulatory factor 2 (Smurf2) in binding concurrently to Smad7, which reduces the binding of Smurf2/Smad7 complex and increases the binding of U[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37406898
sparser
"We have demonstrated specific interactions between UCH37 and inhibitory Smad7, as well as weaker associations with Smad2 and Smad3."
17052192
sparser
"Using GST pull down assays, UCH37 was shown to specifically interact with Smad7 in vitro and in vivo via co-immunoprecipitation with HA-tagged UCH37 in transfected HEK-293 cells."
18687060
signor
"Here, we report a novel interaction between smads and ubiquitin c-terminal hydrolase uch37, a deubiquitinating enzyme that could potentially reverse smurf-mediated ubiquitination. In gst pull down experiments, uch37 bound weakly to smad2 and smad3, and bound very strongly to smad7 in a region that is distinct from the -py- motif in smad7 that interacts with smurf ubiquitin ligases."
16027725