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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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OTULIN inhibits LUBAC. 4 / 4

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"Ectopic expression of OTULIN in HEK293 and HeLa cells inhibits LUBAC dependent NF-kappaB signaling, suggesting that OTULIN is a negative regulator of this signaling pathway 18, 20."

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"OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1 linked polyubiquitin."

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"Moreover, a linear ubiquitin specific DUB, OTULIN, antagonizes LUBAC function in the xenophagy of Salmonella [XREF_BIBR]."

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"LUBAC function is restricted by OTULIN through its docking to the PUB domain of HOIP."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...

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Statements

OTULIN inhibits LUBAC. 4 / 4

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