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Resveratrol inhibits NFKB1. 8 / 17
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"Resveratrol has also been demonstrated to reduce the production of IL-1β and thus inhibit the IL-1β-induced Nf-kB activation, which is involved in the modulation of a variety of signals affecting cell[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Specifically, resveratrol has been found to stimulate brain SIRT1 activity while suppressing NF-kb and enhancing AMPK."
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"It has been shown that resveratrol inhibits the activation of Nf-kB and subsequently down regulates the expression of Nf-kB regulated genes such as interleukin-2 and Bcl-2, leading to cell cycle arrest and increased apoptosis in multiple myeloma cells."
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"The modulatory effects of resveratrol on sirtuins in regulating NFkB activity in diabetic heart are lacking.Activation of SIRT-1 could be useful to inhibit NFkB activity in diabetic heart and thus cou[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, MERS-CoV infection can lead to the production of inflammatory cytokines, while resveratrol can reduce inflammation by interfering and inhibiting the NF-KB pathway (nuclear factor kappa-light-chain-enhancer of activated B cells) protein complex functioning as a transcription factor that has a key role in regulating the immune response to infections, inflammatory processes, autoimmune diseases, septic shocks, viral infections, diseases of the immune system, and tumor processes."
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"The mechanism could be due to the fact that resveratrol is able to activate Sirt-1 and inhibit COX-2, 5-lipoxygenase and NFkB, resulting in less activation of proinflammatory pathways (Buglio et al., 2022)."
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"It has also been shown that resveratrol can downregulate the NF-KB and P38 MAPK signaling pathways, modulating the immune inflammatory response and preventing disease progression."
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"It has been shown that resveratrol inhibits proliferation by downregulating NFkB, inhibits epithelial-mesenchymal transition dependent on TGF β/Smad, decreases the β-catenin-dependent pathway to impede invasion and migration, and influences angiogenesis by inhibiting HIF-1 and expediting its ubiquitination [101,102,103,104]."
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