IndraLab

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USP10 inhibits assembly. 2 / 2

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"Because both USP10 overexpression and G3BP deletion similarly prevent SG formation, the data suggest that USP10 inhibits G3BP-mediated SG assembly downstream of translational arrest/polysome disassembly."

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"Interestingly, this same N-terminal pocket bound by resveratrol has also been shown to interact with the FGDF domains in USP10 and the Alphavirus protein NSP3 [ xref ], which inhibit SG assembly by competing with CAPRIN1 binding."

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IndraLab

Statements

USP10 inhibits assembly. 2 / 2

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