IndraLab

Statements

FMR1 binds KCND2. 10 / 10
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sparser
"We show that FMRP associates with Kv4.2 mRNA, and that absence of FMRP decreases Kv4.2 mRNA translation and protein expression in vivo and in vitro , whereas FMRP overexpression increases protein levels of Kv4.2 3′UTR reporters."
21490210
sparser
"However, our data neither supports nor rules out a direct interaction of FMRP with Kv4.2 mRNA, and future studies will have to further analyze the modalities of FMRP association with and translational regulation of Kv4.2 mRNA."
21490210
sparser
"To analyze if Kv4.2 mRNA might be one of the “unconventional” target mRNAs of FMRP that show reduced translation and protein levels in the FXS mouse model ( xref ; xref ), we next examined whether Kv4.2 mRNA associates with FMRP in brain cortex."
21490210
sparser
"Using Kv4.2-specific quantitative real time PCR analyses of FMRP-coimmunprecipitates, we demonstrated that FMRP associates with Kv4.2 mRNA in mouse cortex ( xref )."
21490210
sparser
"FMRP can bind Kv4.2 mRNA and regulate its translation xref – xref ."
33828309
sparser
"In line with this assumption, analysis of Kv4.2-3′UTR association with several FMRP deletion constructs suggests that the association of FMRP with Kv4.2 mRNA does not seem to be mediated by a single mRNA binding domain, but rather requires multiple domains of FMRP ( xref )."
21490210
sparser
"Of note, this decrease in protein expression is due to direct FMRP–Kv4.2 mRNA binding, and mutation of S499 residue of FMRP reduces the amount of Kv4.2 mRNA bound to FMRP ( xref )."
27147118
sparser
"A previous study showed protein-protein interactions between FMRP and the potassium channel Slack( xref ), however we could not detect any association of FMRP with Kv4.2 protein (data not shown)."
21490210
reach
"FMRP can bind Kv4.2 mRNA and regulate its translation ."
33828309
sparser
"In hippocampal dendrites, FMRP is associated with Kv4.2 mRNA and prevents its translation leading to reduced channel expression at post-synaptic membrane ( xref )."
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