IndraLab

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EGF phosphorylates STAT3 on tyrosine. 11 / 11
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"Pretreatment with Wit for as little as 2-10min inhibited EGF stimulated STAT3 tyrosine phosphorylation partially, and complete inhibition occurred within 15-30min."
24983364
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"We next sought to determine whether the effects of Wit were limited to EGF and IL-6 stimulation of STAT3 and/or STAT5 tyrosine phosphorylation."
24983364
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"Starting with MDA-MB-468 cells, a human breast cancer cell line where EGF is known to induce STAT3 phosphorylation, we demonstrated as shown in XREF_FIG, that Wit inhibited EGF stimulated tyrosine phosphorylation of STAT3, with an IC 50 of about 1-3muM."
24983364
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"In contrast, depletion of Grb2 by RNA interference substantially increases Stat3 tyrosine phosphorylation induced by EGF."
14498832
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"XREF_FIG shows that in the absence of Wit, EGF stimulated the tyrosine phosphorylation of both STAT3 and STAT5."
24983364
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"In the present study, we report that transient expression of Grb2 specifically down-regulates EGF stimulated tyrosine phosphorylation of Stat3, which leads to a repression of Stat3 transcriptional activity."
14498832
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"We further demonstrate that JNK1, activated by its upstream kinase MKK7, negatively regulated the tyrosine phosphorylation and DNA binding and transcriptional activities of Stat3 stimulated by EGF."
10521505
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"As expected, the expression of GSTP1 was effectively blocked by GSTP1 siRNA, and GSTP1 siRNA further enhanced the EGF stimulated tyrosine phosphorylation of Stat3 (XREF_FIG)."
23426146
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"STAT3 is rapidly tyrosine phosphorylated in response to IL-6, ciliary neurotrophic factor, oncostatin M, leukemia inhibitory factor, IL-11, granulocyte colony stimulation factor and epidermal growth factor."
8918689
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"The transient expression of GSTP1 specifically downregulated epidermal growth factor (EGF)-mediated tyrosine phosphorylation of Stat3, and subsequently suppressed the transcriptional activity of Stat3."
23426146
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"Overexpression of GSTP1 inhibited the EGF stimulated tyrosine phosphorylation of Stat3 in a dose dependent manner (XREF_FIG)."
23426146