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"The major findings of this study are as follows : (1) inhibition of M/K v 7 potassium currents causes itch sensation; (2) CQ is an inhibitor of M/K v 7 currents, and inhibitory mechanism involves TRPA1 mediated Ca 2+ influx; (3) CQ induced inhibition of M/K v 7 induces hyper-excitability of DRG neurons, which is likely the mechanism for CQ induced itch sensation."