IndraLab

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USP14 binds Ku-70. 4 / 4
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"We first confirmed the interaction between Ku70 and USP14 by performing immunoprecipitation (IP) of USP14 from HEK 293T cells co-expressing Flag-HA-USP14 and EGFP-Flag-Ku70 using anti-HA, which co-immunoprecipitated USP14 and Ku70 (Figure xref )."
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"Here, we demonstrate that USP14 directly interacts with Ku70, and USP14-mediated deubiquitination regulates DSB- recruitment of Ku70 and downstream NHEJ-core complex assembly."
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"We further confirmed the interaction between endogenous Ku70 and USP14 by IP of USP14 from LNCaP cells followed by immunoblotting for Ku70 (Figure xref )."
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"USP14 directly interacts with Ku70 and targets its ubiquitination."
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