IndraLab

Statements

CASP8 activates CYLD. 9 / 9
| 9
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"Thus, caspase-8 can target CYLD (the cylindromatosis tumor suppressor protein) XREF_BIBR, XREF_BIBR, a deubiquinating enzyme participant of necroptosis, and infection of HeLa cells with L - MV results in some activation of this caspase XREF_BIBR."
23072900
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"Necroptotic signaling is also suppressed by caspase 8 mediated cleavage of RIPK1 and/or CYLD."
23720337
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"This model is consistent with the recent discovery that caspase 8 mediated cleavage of CYLD limits TNF induced programmed necrosis [XREF_BIBR], since caspase 8 is present in the necrosome, but not the TNFR-1 complex."
24098568
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"In normal circumstances, caspase-8 molecule activates apoptosis by blocking the necroptosis and by cleaving RIPK1 and CYLD [XREF_BIBR - XREF_BIBR]."
29980212
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"Caspase-8 also targets the deubquitinase CYLD preventing RIPK1 initiation of necroptosis [XREF_BIBR, XREF_BIBR]."
27710879
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"Following TNF stimulation, aberrant CYLD necroptotic activity is held in check by caspase-8 mediated CYLD processing and inactivation 74."
27158445
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"An alternative explanation for the embellished necroptotic sensitivity observed in casp8 deficient cells has been raised by Ting and colleagues, observing that casp8 mediated cleavage of the E3 ubiquitin ligase CYLD enhances RIP1 and RIP3 dependent necroptosis [XREF_BIBR]."
24856110
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"XREF_BIBR, XREF_BIBR Second, caspase 8 mediated cleavage of CYLD generates a survival signal, whereas the mutation of caspase 8 mediated cleavage site on CYLD switches cell survival to necrotic cell death in response to TNFalpha."
27383048
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"Caspase-8 and FADD in tandem inhibit necroptosis by inhibiting the activity of RIPK1 and RIPK3 and CYLD and promote the advent of apoptosis via the cleavage of PARP-1 [XREF_BIBR, XREF_BIBR]."
29052145