IndraLab

Statements

CASP8 activates CYLD. 13 / 13
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"Contrary to the inactive cFLIP s –caspase-8 heteromer, the cFLIP L –caspase-8 heteromer displays spatially-restricted activity enabling it to cleave RIPK1, RIPK3, and CYLD thereby preventing necroptos[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29195774
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"Necroptotic signaling is also suppressed by caspase 8 mediated cleavage of RIPK1 and/or CYLD."
23720337
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"Caspase-8 also targets the deubquitinase CYLD preventing RIPK1 initiation of necroptosis [XREF_BIBR, XREF_BIBR]."
27710879
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"Within Complex II, caspase-8 (casp8) can negatively modulate the formation of the necrosome by cleaving RIPK1, as well as RIPK3 and CYLD [ 34–36 ]."
29738881
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"In addition to cleaving RIPK1, caspase-8 also mediates the cleavage of CYLD, a deubiquitinating enzyme that promotes necroptosis (43, 44)."
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"This model is consistent with the recent discovery that caspase 8 mediated cleavage of CYLD limits TNF induced programmed necrosis [XREF_BIBR], since caspase 8 is present in the necrosome, but not the TNFR-1 complex."
24098568
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"XREF_BIBR, XREF_BIBR Second, caspase 8 mediated cleavage of CYLD generates a survival signal, whereas the mutation of caspase 8 mediated cleavage site on CYLD switches cell survival to necrotic cell death in response to TNFalpha."
27383048
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"An alternative explanation for the embellished necroptotic sensitivity observed in casp8 deficient cells has been raised by Ting and colleagues, observing that casp8 mediated cleavage of the E3 ubiquitin ligase CYLD enhances RIP1 and RIP3 dependent necroptosis [XREF_BIBR]."
24856110
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"Following TNF stimulation, aberrant CYLD necroptotic activity is held in check by caspase-8 mediated CYLD processing and inactivation 74."
27158445
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"RIPK3 is negatively regulated by caspase-8 and FADD, which induce RIPK3, RIPK1 and CYLD cleavage and thereby inhibit necroptosis [78]."
37688617
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"In normal circumstances, caspase-8 molecule activates apoptosis by blocking the necroptosis and by cleaving RIPK1 and CYLD [XREF_BIBR - XREF_BIBR]."
29980212
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"Caspase-8 and FADD in tandem inhibit necroptosis by inhibiting the activity of RIPK1 and RIPK3 and CYLD and promote the advent of apoptosis via the cleavage of PARP-1 [XREF_BIBR, XREF_BIBR]."
29052145
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"Thus, caspase-8 can target CYLD (the cylindromatosis tumor suppressor protein) XREF_BIBR, XREF_BIBR, a deubiquinating enzyme participant of necroptosis, and infection of HeLa cells with L - MV results in some activation of this caspase XREF_BIBR."
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