IndraLab

Statements

TBK1 binds OPTN and CYLD. 4 / 4
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"Interestingly, our results indicate that the TBK1, Optn, and CYLD complex is disrupted during G2/M phase as a consequence of Optn and CYLD accumulation to the nucleus, leading to enhancement of TBK1 activity and relocalization of its active form to the mitochondria."
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"Our results led us to propose a model for the regulation of TBK1 activity by Optn: In uninfected cells, the complex formed by TBK1, Optn and CYLD would allow constitutive deubiquitination and inhibition of TBK1, thereby limiting its activity in the absence of upstream signaling."
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"Formation of the TBK1, Optn, and CYLD complex is disrupted during the G2/M transition."
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"We then hypothesized that the accumulation of Optn and CYLD to the nucleus during G2/M phase should disrupt the TBK1, Optn, and CYLD complex formation."
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