IndraLab

Statements

USP11 phosphorylates SMAD2. 2 / 2
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"Consistent with this, we were able to show that the decrease in TGFbeta induced SMAD2 phosphorylation by USP11 depletion is abrogated by proteasomal inhibition (20 muM MG132, 3 h before TGFbeta stimulation)."
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"As expected, SMAD7 expression resulted in significant inhibition of TGFbeta induced phosphorylation of SMAD2, which was partially rescued by USP11 (XREF_FIG a)."
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