IndraLab

"Co-immunoprecipitation experiments (Co-IP) were used to analyse the interaction between CYLD and Nrf2 in ORN."

"Nrf2 directly bound to CYLD and was ubiquitinated in ORN cells."

"Nrf2 directly bound to CYLD and was ubiquitinated in ORN cells."

"Co-immunoprecipitation experiments (Co-IP) were used to analyse the interaction between CYLD and Nrf2 in ORN."

"However, the expression of USP4 is decreased in failing human heart as well as in experimental animals with pathological hypertrophy. xref Similarly, CYLD prevents activation and recruitment of TAKl by cleaving the K63 polyubiquitin chain of TRAF2,TRAF6 and NEMO (Figure  xref ), which leads to inactivation of IKK and suppression of downstream of NF‐κB pathway. xref , xref Similarly, the ubiquitination of TRAF‐binding protein (TRIP) is required for the activation of TNFα‐induced NF‐κB. This signalling pathway is controlled by CYLD‐dependent removal of K63‐linked ubiquitination chains of TRIP, which leads to attenuation of TNFα‐dependent NF‐κB signalling. xref CYLD‐Nrf2 axis plays a key role in the cardiac remodelling."