IndraLab

Statements


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"Among these DUBs, POH1, UCHL5 and USP14 are associated with the 19S proteasome; they are often overexpressed in several carcinoma cells, which renders them potentially new therapeutic targets in these cancer cells [ xref – xref ]."

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"In addition to RPN11, UCHL5 and USP14 are also associated with cell survival and cancer progession [ xref , xref ]."

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"There are three important DUBs associated with the 19S proteasome, the JAMM family member POH1 (also known as RPN11/pda1/S13/mpr1), the USP family member USP14 and the UCHs family member UCHL5 (also known as UCH37)."