IndraLab

Statements

CYLD increases the amount of BCL3. 2 / 2
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"19 In support of these early findings, a recent study shows that downregulation of CYLD in melanoma cells by the ubiquitin ligase, Snail, causes constitutive nuclear expression of Bcl3, which seems to promote tumor progression."
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"Levels of Bcl-3 in the cell may be controlled both by gene transcription and also by turnover of the protein itself since a splice variant of the deubiquitinylating enzyme, CYLD, increases the amount of Bcl-3 in the cell and increases cell survival."
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