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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

CYLD increases the amount of BCL3. 2 / 2

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"19 In support of these early findings, a recent study shows that downregulation of CYLD in melanoma cells by the ubiquitin ligase, Snail, causes constitutive nuclear expression of Bcl3, which seems to promote tumor progression."

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"Levels of Bcl-3 in the cell may be controlled both by gene transcription and also by turnover of the protein itself since a splice variant of the deubiquitinylating enzyme, CYLD, increases the amount of Bcl-3 in the cell and increases cell survival."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...