IndraLab

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GRK5 phosphorylates NPM1. 11 / 12
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"Indeed, it has been demonstrated that in the nucleus GRK5 interacts with and phosphorylates nucleophosmin (NPM1) [XREF_BIBR], a multifunctional protein involved in the regulation of cell cycle, centrosomal duplication and apoptosis, that is overexpressed in several cancer types [XREF_BIBR]."
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"Our studies reveal that GRK5 is able to interact with and phosphorylate nucleophosmin (NPM1) both in vitro and in intact cells."
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rlimsp
"NPM1 phosphorylation by GRK5 and PLK1 correlates with the sensitivity of cells to undergo apoptosis with cells having higher GRK5 levels being less sensitive and cells with lower GRK5 being more sensitive to PLK1 inhibitor-induced apoptosis."
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sparser
"GRK5 phosphorylates nucleophosmin, NPM1."
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sparser
"GRK5 phosphorylates NPM1 at Ser-4, a site shared with PLK1, suggesting the possibility of an interplay between GRK5 and PLK1, in the regulation of NPM1."
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"NPM1 phosphorylation by GRK5 and PLK1 correlates with the sensitivity of cells to undergo apoptosis with cells having higher GRK5 levels being less sensitive and cells with lower GRK5 being more sensitive to PLK1 inhibitor induced apoptosis."
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reach
"F. GRK5 phosphorylates nucleophosmin, NPM1."
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rlimsp
"G protein-coupled receptor kinase 5 phosphorylates nucleophosmin and regulates cell sensitivity to polo-like kinase 1 inhibition."
22467873
sparser
"NPM1 phosphorylation by GRK5 and PLK1 correlates with the sensitivity of cells to undergo apoptosis with cells having higher GRK5 levels being less sensitive and cells with lower GRK5 being more sensitive to PLK1 inhibitor-induced apoptosis."
22467873
reach
"G protein coupled receptor kinase 5 phosphorylates nucleophosmin and regulates cell sensitivity to polo like kinase 1 inhibition."
22467873
rlimsp
"Indeed, it has been demonstrated that in the nucleus GRK5 interacts with and phosphorylates nucleophosmin (NPM1)[78], a multifunctional protein involved in the regulation of cell cycle, centrosomal duplication and apoptosis, that is overexpressed in several cancer types [79]."
27326393