IndraLab

Statements

AKT1 phosphorylates TSC2 on T1462. 6 / 6
1 1 3 | 1
biopax:phosphositeplus
No evidence text available
hprd
No evidence text available
19664994
hprd
No evidence text available
15342917
hprd
No evidence text available
12150915
signor
"We demonstrate that, upon activation of PI3K, tuberin is phosphorylated on consensus recognition sites for PI3K-dependent S/T kinases. Moreover, Akt/PKB can phosphorylate tuberin in vitro and in vivo. We also show that S939 and T1462 of tuberin are PI3K-regulated phosphorylation sites and that T1462 is constitutively phosphorylated in PTEN(-/-) tumor-derived cell lines."
12150915
reach
"RT results in high activation of protein kinase B (PKB), which is responsible for the phosphorylation of TSC2 at the Thr1462 site, resulting in TSC2 inactivation and consequently promoting mammalian target of rapamycin complex 1 (mTOR) activation [39]."
39416488