IndraLab

Statements

AKT1 phosphorylates TSC2 on T1462. 6 / 6
1 1 3 | 1
hprd
No evidence text available
12150915
signor
"We demonstrate that, upon activation of PI3K, tuberin is phosphorylated on consensus recognition sites for PI3K-dependent S/T kinases. Moreover, Akt/PKB can phosphorylate tuberin in vitro and in vivo. We also show that S939 and T1462 of tuberin are PI3K-regulated phosphorylation sites and that T1462 is constitutively phosphorylated in PTEN(-/-) tumor-derived cell lines."
12150915
biopax:phosphositeplus
No evidence text available
reach
"RT results in high activation of protein kinase B (PKB), which is responsible for the phosphorylation of TSC2 at the Thr1462 site, resulting in TSC2 inactivation and consequently promoting mammalian target of rapamycin complex 1 (mTOR) activation [39]."
39416488
hprd
No evidence text available
19664994
hprd
No evidence text available
15342917