IndraLab

Statements

SCN5A inhibits Ala-Pro. 3 / 3
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"However, mutations in SCN5A connected with loss-of-function of sodium channel cause Brugada syndrome (BrS) characterized by decreased peak in I Na and reduced upstroke velocity of the AP."
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"Finally, the severely affected Scn5a +/- mice had similar Na v 1.5 mRNA but lower Na v 1.5 protein expression, moderately smaller Na + currents, and reduced AP upstroke velocities than the mildly affected Scn5a +/- mice."
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"AP conduction velocity magnitudes derived by averaging MEA results from local vector analyses, CV *, were reduced by the Scn5a +/- genotype alone."
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