IndraLab

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"In contrast to BAP1, which inhibits RCC by upregulation of STING activity and activation of interferon, UCHL5 promotes RCC by regulating immune infiltration and antigen presentation of B cells, and its increased level in RCC blood samples suggest its potential as a prognostic marker."
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"UCHL3 and UCHL5 slightly enhanced B and T cell infiltration, which may suggest the poor prognosis in RCC."
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"This suggests that UCHL5, like UCHL3, may also promote RCC by regulating immune cell infiltration and activity."
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"And the expression of UCHL5 in RCC tumor cells increased B cells infiltration, suggesting an immunosuppressive correlation with B cells but not with T cells (Fig. 5c, d)."
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