IndraLab

Statements

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"The strong association between BAP1 and HIF1α might determine why BAP1 loss increases the risk of metastasis in certain cancer types such UM."
33446574
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"Finally, to elucidate the mechanism by which BAP1 suppresses invasion and metastasis in LAC cells, we analyzed the expression levels of metastasis related proteins in transfected H1299 cells and H1650 cells using IB, respectively."
27553041
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"We find that this process requires VCAM mediated adhesion between UM cells and ECs and that loss of the metastasis suppressor BAP1 enhances TEM."
25506912
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"BAP1 promotes progenitor cell differentiation into melanocytes by increasing MITF expression and BAP1 loss may promote metastasis in UM by remodeling the epigenome to resemble that of stem-like migratory neural crest cells."
33060121
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"Knockdown of BAP1 in TNBC cells inhibited tumorigenesis and metastasis, which could be partially rescued by restoration of KLF5 expression, suggesting that KLF5 mediates, at least in part, the breast cancer promoting function of BAP1 [XREF_BIBR]."
27844253
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"Prompted by these transcriptomic findings, we wished to explore further the possibility that BAP1 inhibits metastasis of uveal melanoma cells by maintaining their differentiated state and impeding their reversion to a stem like state."
23915344
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"The authors concluded that loss of BAP1 might increase susceptibility to uveal melanoma metastasis and serve as a valuable therapeutic target."
22260482
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"Our results reveal a novel route of transendothelial migration for uveal melanoma cells, and they provide insight into the mechanism by which loss of BAP1 promotes metastasis."
25506912
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"XREF_BIBR, XREF_BIBR The precise molecular explanation for why loss of BAP1 leads to metastasis in UM remains unclear."
23714557
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"19 However, GNA11 mutations are also more common in tumors involving the ciliary body, which is an independent risk factor for metastasis, and in tumors with mutations in the metastasis suppressor BAP1 (Breast cancer 1, early onset (BRCA1)-associated protein 1) (see below), so it remains possible or even likely that the association between GNA11 and metastasis is not causal."
24480708
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"It will be important to elucidate how this effect of BAP1 loss promotes metastasis and how to reverse this effect therapeutically."
23915344
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"26 The exact mechanism (s) by which loss of BAP1 mediates primary uveal melanoma metastasis is currently being investigated."
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"There was a low transcript number for BRCA1 associated protein 1 (BAP1), which when highly expressed suppresses metastasis [XREF_BIBR]."
32655131
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"XREF_BIBR, XREF_BIBR The precise reason why loss of BAP1 promotes uveal melanoma progression and metastasis remains unclear and is the subject of intense investigation."
24480708
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"These studies could also lead to context-selective discovery of novel therapeutic strategies and understanding whether BAP1 loss promotes metastasis."
33060121