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ZUP1 inhibits Interferon. 16 / 16
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"For example, viral DUB activity of CCHFV OTU and equine arteritis virus OTU suppresses type I IFN signaling during infection (7–9), whereas the turnip yellow mosaic virus DUB counters Ub-mediated proteasomal degradation of its polymerase (17)."
31337717
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"These results therefore suggest that host cells lack the ability to produce type I IFN in response to MHV-A59 infection.Because ubiquitination plays an important role in the RIG-I-mediated IFN induction cascade 20, and because PLpro domain 2 (PLP2) domain of MHV-A59 contains a conserved DUB motif 22, we hypothesized that the DUB activity of PLP2 domain might block the IFNβ response during MHV-A59 infection."
18957937
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"This DUB activity may remove ubiquitin from innate immune signaling factors to suppress the induction of an antiviral state, and indeed was shown to reduce IFN signaling in biochemical experiments using PL2 pro overexpression for several coronaviruses, including SARS-CoV (Matthews et al. 2014a; ) and MERS-CoV Clementz et al. 2010; Bailey-Elkin et al. 2014) ."
28643204
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"These results therefore strongly suggested that PLP2 domain that associated with TBK1/IRF3 complex may contribute to the suppressed IFN response via inactivation of TBK1/IRF3 by its DUB activity in MHV-A59 infected cells.Therefore, by tempering the ubiquitination of both TBK1 and IRF3, and subsequent phosphorylation of both, PLP2 would provide a favorable steric conformation for inter-molecular interaction between inactivated TBK1 and IRF3."
21364999
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"1108 npg therefore suggest that host cells lack the ability to produce type I IFN in response to MHV-A59 infection.Because ubiquitination plays an important role in the RIG-I-mediated IFN induction cascade [20] , and because PLpro domain 2 (PLP2) domain of MHV-A59 contains a conserved DUB motif [22] , we hypothesized that the DUB activity of PLP2 domain might block the IFNβ response during MHV-A59 infection."
18957937
reach
"This DUB activity may remove ubiquitin from innate immune signaling factors to suppress the induction of an antiviral state, and indeed was shown to reduce IFN signaling in biochemical experiments using PL2pro overexpression for several coronaviruses, including SARS-CoV (Matthews et al. 2014a; Li et al. 2016) and MERS-CoV (Chen et al. 2007; Clementz et al. 2010; Bailey-Elkin et al. 2014)."
28643204
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"We found that the DUBmut virus replicates similarly to the wild-type (WT) virus in cultured cells, but the DUBmut virus activates an IFN response at earlier times compared to the wild-type virus infection in macrophages, consistent with DUB activity negatively regulating the IFN response."
32188728
eidos
"For example , the UPS was essential for coronavirus replication ( Raaben et al ., 2010 ) , whereas coronavirus papain-like proteases can act as DUBs that block type I IFN production ( Clementz et al ., 2010 ) ."
30408499
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"Both of these genes encode DUB that stimulate a type I IFN negative feedback mechanism by removing K63-linked poly ubiquitin chains on critical components of the antiviral signaling pathway such as RIG-I (Tao et al., 2020) and TBK1 (Cai et al., 2018)."
34566579
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"It is known that PLpro exhibits deubiquitinating (DUB) activity and antagonizes the induction of type-1 interferon (IFN), the interferon-stimulated gene 15 (ISG15) is the most overexpressed gene upon IFN stimulation and it’s involved in marking newly synthesised protein during an antiviral response."
34515981
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"For example, viral DUB activity of CCHFV OTU and equine arteritis virus OTU suppresses type I IFN signaling during infection (7) (8) (9) , whereas the turnip yellow mosaic virus DUB counters Ub-mediated proteasomal degradation of its polymerase (17) ."
31337717
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"In addition, PLpro exhibits deubiquitinating (DUB) activity and antagonizes the induction of type-1 interferon (IFN)."
28112000
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"In addition, African swine fever virus, a large DNA virus, has a DUB that is thought to block the production of interferon by unknown mechanisms."
| PMC
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"One such multifunctional domain is the coronavirus papain-like protease (PLP), which processes the viral replicase polyprotein, has deubiquitinating (DUB) activity, and antagonizes the induction of type I interferon (IFN)."
20181693
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"We found that the DUBmut virus replicates similarly as the wild-type virus in cultured cells, but the DUBmut virus activates an IFN response at earlier times compared to the wild-type virus infection in macrophages, consistent with DUB activity negatively regulating the IFN response."
| DOI
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"The conclusion that DUB activity of PLP2 of coronaviruses antagonizes IFN response is contradicted by a recent study in which DUB activity of PLP2 of another coronavirus HCoV-NL63 is not required to inhibit IFN response [38]."
21364999