IndraLab

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"The results showed that DMY could significantly relieve vascular hyporesponsiveness caused by LPS and this effect could be blocked by MaxiK and K inhibitors incubation previous to NE treatment, which suggests that DMY may inhibit the inflammatory response, thus reverse the over-excited MaxiK and K channels in VSMCs.Accumulating evidence shows that the activity of ion channels, especially the potassium channel on ASMCs, plays a pivotal role in affecting the contractile state of the peripheral arteries."
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"Furthermore, intradermal injection of the toxins results in pronounced skin inflammation, which either resolves quickly within a few h (SLO induced inflammation) or presents a chronic process with ongoing inflammation for weeks (alpha-toxin)."
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