IndraLab

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MTOR activates HIF1A. 143 / 149
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"Furthermore, the inhibitors of PI3K and mTOR, PI3K and AKT, and ERK 1/2 pathways did not attenuate increased HIF-1alpha protein by bilirubin treatment in HK2 cells."
25317019
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"HIF-1alpha is induced by mTOR and mediates glycolytic activity, thereby contributing to the Th17 cell or Tregs lineage switch."
34026764
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"In some cell types, mTOR may also promote HIF-1alpha stabilization and/or TAD function, although the molecular mechanisms are not completely understood."
22811423
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"It was also shown that extracellular signals activate mTOR, which in turns triggers HIF-1alpha induction though transcriptional regulation [XREF_BIBR]."
26204490
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"In particular, in tumors AMPK negatively regulates the Warburg effect, inhibiting the lipid biosynthesis and mTOR mediated HIF1alpha translation and stimulating the OXPHOS and the fatty acid oxidation [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
29865240
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"HIF-1alpha activated by mTOR signaling was involved in this process and could be a therapeutic target to inhibit the malignant transformation of osteosarcoma cells."
33613706
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"Unexpectedly, in our in vivo and in vitro systems, we found that PKM2 was upregulated independent of c-Myc and AKT and mTOR (the upstream inducer of HIF-1alpha)."
22617155
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"Activation of mTOR upregulated HIF-1alpha, whereas inhibiting PHD1 activity reduced Foxp3 + Tregs and promoted Th17 cell differentiation in IR induced liver injury."
30185770
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"MTOR activated HIF1alpha promotes Th17 cell development by enhancing the glycolytic capacity of Th17 cells as well as supporting RORgammat mediated gene transcription."
29514093
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"Our data indicates the EGFR-mTOR ultimately activate HIF-1a to further support the replication of the Salmonella ."
33868285
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"MTOR activates hypoxia inducible factor-1alpha and inhibits neuronal apoptosis in the developing rat brain during the early phase after hypoxia-ischemia."
22178140
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"Hypoxia inducing factor (HIF-1alpha) is activated by mTOR pathway and by constitutive NF-kappaB and AP1 production."
29081773
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"Because activation of HIF-1alpha by mTOR is regulated through a direct interaction between HIF-1alpha and regulatory associated protein of mTOR (Raptor) [XREF_BIBR], we determined whether the PEM blocked the interaction between Raptor and HIF-1alpha in vivo."
25983747
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"AKT1 stimulates mTOR kinase, which activates transcription factor HIF1A even at the normoxic conditions [ xref ]."
27034740
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"As shown in Fig. 2h , HIF1alpha stabilization resulting from APIP overexpression and hypoxic stress was remarkably inhibited by the treatment with LY294002 , a PI3K inhibitor , or rapamycin , an mTOR inhibitor , suggesting that PI3K-AKT and mTOR contribute to the increase in HIF1alpha levels via APIP under hypoxia ."
31263105
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"It is noteworthy that hypoxia enhanced mTOR (Target of rapamycin) can stimulate the translation of HIF-1alpha, while HIF-1 inhibits the mTOR pathway, forming a negative feedback loop [XREF_BIBR]."
25823824
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"We reported that the mTOR pathway promotes the synthesis of the HIF-1alpha protein in glucose- and reoxygenation dependent manners in irradiated tumors [XREF_BIBR]."
26983985
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"Increased glycolysis is in part due to activation of HIF-1α by mTOR, which are both critical signaling pathways for proper Th17 differentiation."
32690659
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"Activation of the Akt/mTOR signaling and suppression of hypoxia-inducible factor 1-alpha (HIF-1α) following SARS-CoV-2 infection increases viral replication (Appelberg et al., 2020)."
35882309
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"MTOR also activates HIF-1alpha, NF-kappaB, and c-Myc."
31198853
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"MTOR may upregulate NOX4 expression via HIF1, because mTOR can activate HIF1 and NOX4 is a new target gene of HIF1 ( xref – xref )."
24605290
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"More importantly, we found that tPA induced mTOR mediated HIF-1alpha accumulation leads to the recruitment of the neuronal transporter of glucose GLU3 to the neuronal plasma membrane."
26347605
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"In addition, expression of glucose transporters and the isozyme 1 of pyruvate dehydrogenase kinase (PDK1) are increased by mTOR mediated HIF-1alpha (hypoxia inducible factor 1alpha) translation, driving glycolysis for ATP generation in the absence of oxygen and mitochondrial respiration [XREF_BIBR]."
28250388
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"Indeed, our data suggest that PTH activates cAMP and PKA signaling to increase the activity of mTOR, which can directly regulate Hif-1alpha translation."
26273518
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"HIF-1alpha is reportedly activated by mTOR (Land & Tee,2007) and has been further proven to inhibit neuronal apoptosis in rat brains after hypoxic-ischemic injury (X. Wang, Li, Wu, Bu, & Qiao,2016)."
32475084
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"XREF_BIBR, XREF_BIBR, XREF_BIBR Several indirect methods for targeting HIF-1alpha signaling exist, including mTOR inhibition to prevent HIF-1alpha synthesis, histone deacetylase inhibition to decrease HIF driven transcription, and unfolded protein response inhibition to decrease transcription that is dependent on HIF cofactors such as XBP1."
28825044
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"MTOR activation causes activation of HIF-1α and this upregulates lysyl oxidase (LOX) activity."
26410619
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"As p4EBP and pS6K protect mRNAs including HIF-1a mRNA from degrading, we deduced that ERK and mTOR pathways which regulate the two proteins positively were relative to CP increasing HIF-1a and protecting pBVECs."
28367097
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"Instead of promoting the transcription and stabilisation of HIF1alpha, LIMS1 facilitates the translation of HIF1A, which is mediated by the AKT and mTOR pathway."
30679163
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"HIF1alpha induction by mTOR represents a metabolic checkpoint for the differentiation of T H 17 and T reg cells."
21708926
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"Activation of the mTOR signaling pathway can stimulate hypoxia inducible factor-1alpha (HIF-1alpha), which is responsible for sustained glycolytic reprogramming in DC."
33123131
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"However, inhibition of mTOR by rapamycin pretreatment downregulated phospho-mTOR, phospho-p70S6K, and HIF-1alpha and upregulated PHD1 after LPS stimulation."
30185770
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"MTOR upregulates c-Myc and HIF1alpha although only c-Myc is required for the glycolytic switch as its early upregulation is crucial in the activation process of T cells."
28447025
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"To investigate the association between tPA induced mTOR activation and tPA induced HIF-1alpha accumulation in neurons we performed similar observations in Wt neurons following one hour of incubation with tPA alone or in combination with rapamycin."
22815500
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"It is reported that the AKT and mTOR pathway up-regulates HIF1alpha, which is the upstream regulator of VEGFA 52."
29193730
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"These include increased HIF-1alpha production by activated mTOR signaling XREF_BIBR and VHL independent degradation by heat shock protein 70 (Hsp70) and carboxyl terminus of HSP-interaction protein (CHIP) XREF_BIBR."
25420025
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"As shown in Figure XREF_FIG, the inhibition of the mTOR signal by RAPA decreased hypoxia inducible factor 1-alpha (HIF-alpha) and glucose uptake and therefore decreased glycolysis."
26375670
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"In summary, inactivation of the mTOR and P70S6K pathway by REDD1 and hypoxia leads to increased PP2A function, PHD2 dephosphorylation, and, thus, HIF1alpha stabilization."
28199842
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"Based on these data and other results not discussed here, we propose a model whereby tPA either released in the synaptic cleft following the onset of cerebral ischemia or intravenously administered interacts with LRP1, leading to NMDAR mediated mTOR activation, mTOR induced HIF-1alpha accumulation, HIF-1alpha-induced recruitment of the neuronal transporter of glucose GLUT3 to the neuronal plasma membrane, and GLUT3 mediated uptake of glucose by neurons in the ischemic brain."
26347605
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"Blocking mTOR pathway in SCC tumors was also shown to prevent accumulation of HIF-1alpha resulting in inhibition of processes involved in glucose metabolism as well as decrease in pro angiogenic factors such as vascular endothelial growth factor (VEGF) XREF_BIBR."
23185335
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"MTOR-activated HIF1α promotes Th17 cell development by enhancing the glycolytic capacity of Th17 cells as well as supporting RORγt-mediated gene transcription ( xref ; xref )."
29514093
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"Since activation of Akt and mTOR is known to enhance HIF-1alpha translation, it is likely that Skp2 may also upregulate HIF-1alpha translation and induces HIF-1-dependent glycolysis through the Akt and mTOR pathway."
22632973
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"Most importantly, mTOR is an upstream activator of HIF-1alpha in cancer cells, which is a subunit of a transcription factor that upregulates the expression of nearly all of the genes involved in the glycolytic pathway."
27437085
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"It is not known precisely how mTOR signaling promotes the translation of HIF-1alpha, but HIF-1alpha is likely to be particularly sensitive to fluctuations in the rate of protein synthesis due to its short half-life (approximately 5 minutes) under normoxic conditions."
23376032
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"The mTOR pathway regulates cell proliferation, adhesion, migration, metabolism, and survival, and mTOR modulates angiogenic factors by activating either HIF-1alpha or NOS 2."
26650611
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"MTOR mediated HIF-1alpha induction plays an important role in activating glycolysis [XREF_BIBR]."
32005273
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"Pharmacologic inhibitors of the Trk tyrosine kinase, PI-3 kinase and mTOR paths prevent NGF stimulated increases in HIF-1alpha and VEGF."
21145972
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"XREF_BIBR mTOR activates HIF1alpha and inhibits neuronal apoptosis in the developing rat brain."
26937175
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"Since FLT3 signaling activates the PI3K-mTOR pathway [XREF_BIBR], and since mTOR activation increases HIF1alpha protein accumulation [XREF_BIBR - XREF_BIBR], it would be intriguing to test whether FLT3 mutations cause HIF activation in AML."
25857287
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"Several studies have documented a positive role for the mTOR target HIF1alpha in the TLR driven activation of BMDCs and cDCs XREF_BIBR, XREF_BIBR, XREF_BIBR."
25534620
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"HIF-1alpha is induced by mTOR and mediates glycolytic activity , thereby contributing to the Th17 cell or Tregs lineage switch ( Shi et al ., 2011 ) ."
34026764
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"Hypoxic induction of HIF-1alpha by mTOR downstream of PI3K led to the expansion of CD133 + glioma CSCs, which was enhanced by EGFR signaling demonstrating possible crosstalk between the two pathways."
20716638
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"From XREF_FIG D, it was observed that vanillin does not alter phosphorylation of 4E-BP1, eIF4E, and S6 kinase, suggesting that mTOR mediated de novo HIF-1alpha protein synthesis is not responsible for the reduction of HIF-1alpha by vanillin."
28257048
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"Increased [Ca +2] i activates the classical PKC isoforms (PKCalpha and PKCbeta), which in turn activate mTOR, a kinase that promotes HIF-1alpha protein synthesis."
18651560
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"In some cases, oncogenic mTOR signaling can actively promote cap dependent translation of HIF-1alpha."
27748764
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"Among them, mTOR stimulates HIF1alpha, a main transcription factor for VEGF XREF_BIBR."
20131403
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"Recently, Seok et al. [XREF_BIBR] demonstrated that HIF-1alpha stimulated the expression of miR-382, which targeted PTEN and thus could facilitate the PI3K and mTOR mediated HIF-1alpha signaling, e.g. potentiate tumor angiogenesis."
27114850
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"HIF1alpha expression was regulated by mTOR signaling and knockdown of HIF1alpha with two distinct short-hairpin RNAs (shRNAs) decreased PGAM1 expression in both Tsc2 -/ - cells and Pten -/- cells (Figs."
29362480
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"Under hypoxic conditions, mTOR activation enhances the activity of HIF1alpha by inhibiting proteolytic degradation, resulting in elevated VEGF expression; this effect is reversible by rapamycin [21,23[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21329734
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"Activation of AKT / mTOR can stimulate elevated HIF-1alpha protein levels ( Kaidanovich-Beilin and Woodgett , 2011 ) ."
34917069
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"Indeed, even if most drugs targeting hypoxia are made to annihilate VEGF, another major target is the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathw[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29759564
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"We observed that insulin up-regulated PKM2 expression, through PI3K and mTOR mediated HIF1alpha induction, but significantly reduced PKM2 activity independent of this pathway."
23837608
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"Lymphangiogenic growth factors VEGF-C and VEGF-D are also expressed in the LAM lesion, most likely through mTOR driven HIF1alpha pathway activation."
28099079
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"Garcia-Maceira and Mateo demonstrated that inhibiting the phosphorylation of Akt and mTOR occurred with loss of the expression of HIF-1alpha, whereas inhibition of the Akt and mTOR pathway decreased the translation of HIF-1alpha and ultimately led to apoptosis of tumor cells."
29436645
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"Moreover, pharmacologic inhibition of the Trk TK, PI-3kinase or mTOR pathways blocks NGF induced increases in HIF-1alpha and VEGF production."
21145972
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"Furthermore, the mTOR complex component Raptor interacts with HIF-1alpha via an mTOR signaling motif located in HIF-1alpha, thereby promoting HIF-1alpha activity 43."
26045163
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"Calcium dependent activation of PKCalpha and mTOR was reported to induce HIF-1alpha protein synthesis in PC12 cells exposed to CH for 3 h."
18651560
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"The siRNA knockdown of mammalian target of rapamycin (Mtor) reversed the induction of HIF-1alpha found in CM."
30071127
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"These data are consistent with a model whereby loss of TSC2 results in activation of mTOR, which in turn upregulates HIF-1alpha."
12957289
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"In addition, STAT3 can promote EMT progression, and HIF-1alpha, PKM2 and STAT3 are all modulated by mTOR."
33262823
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"Furthermore, rapamycin, a selective inhibitor of mTOR, and hence of cap related translation, blocked the accumulation of c-Myc, XIAP, VEGF, and Hif-1alpha in K and E cells, but not in L and BP cells (XREF_FIG)."
17622357
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"Drugs may also act indirectly by antibody binding of elevated levels of extracellular angiogenic growth factors eg, bevacizumab (Avastin (R), Genentech), acting on overexpressed receptors on tumor cells themselves eg, sunitinib, sorafenib (Nexavar (R), Bayer) or by inhibiting related pathways such as mTOR upregulation of VEGF and HIF1alpha eg, temsirolimus (Torisel (R), Wyeth)."
19707433
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"We further explored whether PI3K, Akt, and mTOR signals were involved in adiponectin induced HIF-1alpha activation in human chondrosarcoma cells."
26468982
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"It has been reported that mTOR could positively regulate HIF-1alpha activation through the PI3K/AKT/mTOR signaling pathway [XREF_BIBR]."
| PMC
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"However, the activity of mTOR, another member of the PIKK family, was inhibited by hypoxic stress, thereby suppressing HIF-1alpha protein translation."
19406746
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"Treatment of macrophages and DCs with LPS increases expression of the transcription factor HIF-1α [35,36], possibly by mTOR-dependent activation of HIF-1α which occurs through interaction of the Raptor component of mTOR with its signaling motif located in the N terminus of HIF-1α [37]."
34361061
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"Another contributing factor to metabolism via PI3K/Akt/mTOR signaling is through HIF-1alpha, mediated by upstream mTOR [XREF_BIBR]."
32316322
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"MTOR activates HIF-1alpha."
30151352
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"By activation of mTOR, c-Myc, and HIF-1alpha will be stimulated, which results in an increase in genes that promote VEGF associated angiogenesis, proliferation (cyclin D1), and cell survival (survivin) [XREF_BIBR]."
28635679
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"These include increased HIF-1alpha production by activated mTOR signalling XREF_BIBR and VHL independent degradation by heat shock protein 70 (Hsp70) and carboxyl terminus of HSP-interaction protein (CHIP) XREF_BIBR."
24563687
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"MTOR activates HIF-1α."
30151352
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"IDF-11774 treatment resulted in increased phosphorylation of AMPK, which inactivates ACC and suppressed the phosphorylation of mTOR and 4EBP1, thereby ultimately attenuating the translation of HIF-1alpha (XREF_FIG)."
28569777
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"For example, mTOR activates the translation of HIF-1alpha even under normoxic conditions, thereby upregulating glucose uptake and aerobic glycolysis (see below)."
25037158
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"Since mTOR activation is needed to prevent HIF1alpha degradation, HIF1alpha seems to be increased after 30 min of visfatin treatment."
21329734
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"Independent of mTOR activity enhancing translation of HIF-1alpha, regulation at the protein level is a highly complex process 14."
27343361
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"Inhibition of mTOR signaling by RPM can directly suppress the translation process of HIF-1alpha and its transcriptional activities [XREF_BIBR, XREF_BIBR]."
23213008
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"MTOR activation causes activation of HIF-1alpha and this upregulates lysyl oxidase (LOX) activity."
26410619
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"Some examples include the activation of regulatory subunit HIF-1α by Akt and mTOR [ xref ], the inhibition of Myc by HIF under hypoxic conditions and cooperation between the two molecules to promote cancer cell growth [ xref ], and the inhibition of HIF-1α via high p53 expression [ xref ]."
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"MTOR activates hypoxia-inducible factor 1 (HIF-1) and initiates the c-Myc-hnRNPs–mediated alternative splicing, which leads to aerobic glycolysis in cancer cells ( xref , xref , xref )."
32195169
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"Further mechanistic studies revealed that increased ROS result in an increase in intracellular calcium that activates protein kinase C and the mammalian target of rapamycin (mTOR), which mediate increased HIF-1alpha synthesis and stability (XREF_FIG)."
28221004
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"MTOR activates HIF-1α under hypoxic condition to support tumor cell survival ( xref )."
26248874
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"In RPE cells, insulin activates mTOR (XREF_FIG), which in turn increases translation of the HIF-1alpha mRNA, transiently induces HIF-1alpha and the HIF-1alpha-dependent transcriptional response."
24810050
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"However, Yuan et al. recently reported that cycling hypoxia up-regulates mTOR regulated synthesis of HIF-1alpha protein, which leads to increased transcriptional activity."
19929412
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"Inhibition of the mTOR pathway can also be used to inhibit HIF-1alpha translation."
30708988
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"Normally, mTOR activity upregulates the production of HIF-1alpha by regulating the level of HIF1A mRNA transcripts."
27126953
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"In some other studies, the mTOR kinase inhibitor impairs production of HIF-1alpha in kidney tumor cell lines under hypoxic condition."
24890366
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"In addition, mTOR enhances the translation of the mRNA encoding HIF-1alpha."
25657648
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"Downstream target of Akt implicated in the positive regulation of HIF-1alpha is the mammalian target of rapamycin, mTOR, which likely upregulates HIF-1alpha through a translation dependent pathway."
27431580
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"The phosphorylation of Akt and mTOR can intensify the hypoxic induction of HIF-1alpha at the translational level, and promotes the stabilization and activation of HIF-1alpha, which regulates intracellular glucose utilization and angiogenesis, eventually promoting the growth of tumor cells."
29436645
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"Furthermore, because increased HIF-1alpha synthesis is mediated by the AKT and mTOR signaling pathway, an increase in the activity of this pathway by miR-382 might crucially increase angiogenesis by inducing VEGF via HIF-1alpha."
24914051
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"It seems that mTOR activates the HIF-1alpha signaling through increasing the transcription and translation of HIF-1alpha rather than inhibiting its degradation [XREF_BIBR, XREF_BIBR]."
27114850
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"The mTOR gene promotes HIF-1alpha abundance, resulting in HIF-1alpha-associated glycolytic gene expression, such as glucose transporter, HKII and LDH."
21196269
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"It contributed to the upregulation of mTOR , which further led to the upregulation of HIF1alpha ."
36937390
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"It has been previously shown that in some neoplasms mTOR is an upstream activator of HIF-1alpha protein, enhancing its gene transcription XREF_BIBR - XREF_BIBR."
25166211
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"In kidney cancer cells, the ability of mTOR to promote Hif1alpha translation has also been studied [XREF_BIBR]."
27148974
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"MTOR signaling enhances the activation of Hypoxia inducible factor 1A (Hif1alpha, 3.389) that is increased by hypoxia."
22688403
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"Moreover, it has been suggested that mTOR had no effect on HIF-1alpha stability and promotes the accumulation of HIF-1alpha protein, mainly by enhancing its synthesis [XREF_BIBR, XREF_BIBR]."
27187382
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"Upon stimulation by growth factor or oncogenic signaling, mTOR increases the synthesis of transcription factors Myc and hypoxia inducible factor-1alpha (HIF-1alpha) via internal ribosome entry site (IRES)-dependent translation."
29212302
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"This LKB1 dependent reprogramming of cell metabolism is dependent on the hypoxia inducible factor-1alpha (HIF-1alpha), which accumulates under normoxia in LKB1 deficient cells and is antagonized by inhibition of mTOR complex I signaling."
24550282
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"Finally, the inhibition of the mTOR pathway prevented the HIF-1alpha activation induced by CM."
30071127
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"We demonstrated that MB induced neuronal protection is mediated via activation of HIF-1, and proposed that MB stabilizes and increases HIF-1, a regulatory subunit of HIF-1 by 1) increasing glucose metabolism, culminating in increased endogenous pyruvate, which is consistent with increased ATP concentration, 2) activating EPO and mTOR signaling pathways, and 3) stimulating nuclear localization of HIF-1alpha."
26047733
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"Phosphoinositide 3-kinase (PI3K) pathway and its downstream effectors, mTOR and P70S6 kinase, mediate increase in HIF-1alpha translation."
25317019
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"MTOR activates HIF-1alpha under hypoxic condition to support tumor cell survival."
26248874
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"Inhibition of either PI3K or mTOR abolished accumulation of HIF-1alpha triggered by Exendin-4, suggesting that such event occurs downstream of mTOR."
28572610
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"ATF3 deficiency promoted mTOR and p70S6K phosphorylation, activated high mobility group box 1 (HMGB1) and TLR4, inhibited prolyl-hydroxylase 1 (PHD1), and increased HIF-1alpha activity, leading to Foxp3 downregulation and RORgammat and IL-17A upregulation in IRI livers."
30185770
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"Taken together with the effects of cycloheximide (XREF_FIG) and the known role of mTOR in promoting HIF-1alpha protein synthesis, these results suggest that the mTOR dependent increase in HIF-1alpha reflects increased HIF-1alpha synthesis, whereas the mTOR independent effect reflects decreased HIF-1alpha degradation during IH as a result of decreased prolyl hydroxylation."
18651560
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"PKM2 up-regulation has been shown to occur through mTOR mediated HIF-1alpha stabilization and c-Myc-heterogeneous nuclear ribonucleoprotein (hnRNP)-dependent regulation [XREF_BIBR]."
32252351
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"MTOR activation is clearly linked to the pathology of the ccRCC and indirectly supports HIF1alpha dependent transcription : mTOR inhibitors (temsirolimus, everolimus) are now commonly used in the clinic."
24982684
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"The HIF1alpha and VEGF signaling pathway, which regulates angiogenesis, is activated by upstream mTOR signaling."
26648539
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"Expression of HIF-1alpha in Th17 cells requires mTOR activation, and thus inhibition of mTOR by rapamycin blocks HIF-1alpha induction and expression of glycolytic enzymes in Th17 cells."
22905034
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"Pharmacologic inhibitors of the Trk tyrosine kinase, PI-3 kinase, and mTOR pathways prevent NGF stimulated increases in HIF-1alpha and VEGF."
24615084
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"MTOR integrates extracellular growth signals with such cellular responses as proliferation, autophagy, metabolism, cell growth, and survival. xref mTOR activates HIF1α and inhibits neuronal apoptosis in the developing rat brain. xref , xref In contrast, inhibition of mTOR activity suppresses the expression of HIF1α, which determines sensitivity to mTOR inhibitors in cancers. xref , xref Deregulation of HIF1α appears to be essential to the disease process."
26937175
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"This increase in HIF1 protein is regulated at least in part by mTOR stimulated translation of HIF1alpha (Bernardi et al., 2006; Semenza, 2003)."
18158893
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"Thus, the HIF-1-induced, KLHL20 mediated PML degradation together with the PML induced, mTOR mediated HIF-1alpha downregulation should constitute a double negative feedback loop to maximize HIF-1alpha accumulation in hypoxia."
27200299
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"RAC-alpha serine/threonine protein kinase 1 or AKT1 activates mechanistic target of rapamycin or mTOR, which in turn activates HIF1A, whereas the tumor suppressor liver kinase B1 (STK11) activates AMP activated protein kinase or AMPK (PRKAA1) which can inhibit the activity of mTOR."
26725848
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"Blocking ATF3 deficiency induced mTOR signaling inhibits TLR4 and HIF-1alpha signaling, promotes Foxp3 + Tregs, and inhibits Th17 cell differentiation in vitro."
30185770
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"PKC inhibits PHD activity (stabilizing the HIF-1 complex) and induces mTOR dependent synthesis of new HIF-1alpha, enabling longer lasting stabilization of HIF-1 and greater VEGF expression."
21613481
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"As discussed above, inhibition of GSK-3 activates mTOR, and mTOR activation increases HIF-1alpha translation and activates HIF-1alpha target genes including vascular endothelial growth factor."
22319467
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"MTOR activates HIF1alpha through increasing its expression [XREF_BIBR, XREF_BIBR - XREF_BIBR]."
29362480
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"Through the activation of its downstream mediators including the 40S ribosomal S6 kinases, mTOR can also activate hypoxia-inducible factor 1 (HIF-1)."
20630061
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"MTOR also activates HIF-1α, NF-κB, and c-Myc."
31198853
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"Also, mTOR downstream signaling of HIF1alpha which further induces glycolytic pathway selectively enhances Th17 development over Treg by activating transcription factor RORgamma [XREF_BIBR]."
27774525
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"MTOR controls production of HIF-1alpha, driving the expression of hypoxic stress response genes that include the same angiogenic growth factors."
24198638
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"Additionally, Inhibition of mTOR via rapamycin treatment prevents HIF-1alpha and HIF-2alpha stabilization under hypoxia."
30013485
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"Interestingly, Knaup et al. found that under severe hypoxia, no influence of mTOR inhibitors was observed; thus, the stimulation of HIF1alpha by mTOR may only be relevant under mild hypoxia or even normoxia [XREF_BIBR]."
29137374
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"Thus , IL-17A directly and potently induces mTOR to up-regulate HIF1alpha under both normoxic and hypoxic conditions ( Fig. 5H ) ."
35709248
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"MTOR activation enhances the activity of HIF1alpha by inhibiting proteolytic degradation, resulting in elevated VEGF expression."
28298952
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"MTOR activates HIF1α through increasing its expression [ xref , xref – xref ]."
29362480
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"MTOR controls production of HIF-1alpha, an important protein in RCC, where its unregulated activity is causally related to disease pathogenesis."
21584218
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"MTOR (mammalian target of rapimycyin) increases the surface expression of GLUTs and activates HIF1, and is itself activated by Akt/PI3K ( xref )."
22431437
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"Activation of mTOR signaling leads to increase in protein synthesis of HIF1alpha in response to growth factors and PI3K and Akt signaling, and thus, leads to enhanced expression of glycolytic enzymes."
22792411
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"Independent of mTOR activity enhancing the translation of HIF-1alpha, regulation at the protein level is a highly complex process [14]."
27343361
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"MTOR and topoisomerase I inhibitors decrease HIF-1alpha accumulation leading to a major antitumour effect mainly when combined [XREF_BIBR]."
23226965